UTILIZAÇÃO DO ESPECTRÔMETRO DE ABSORÇÃO ATÔMICA PARA DETERMINAÇÃO DE CLORIDRATO DE METFORMINA E CLORIDRATO DE RANITIDINA EM MEDICAMENTOS

The utilization of atomic absorption spectrometer for metformin (MET) and ranitidine (RAN) chlorohydrates determination in medicines is proposed. The spectral lines of nickel and aluminum at 232.0 and 308.2 nm were selected for MET and RAN absorbance monitoring, respectively. The results were compared to those obtained by molecular absorption spectrometry at ultraviolet range (spectrophotometry) and condutometric titration. The figures of merit obtained were adequate for MET and RAN determination in medicines. The limit of detection (LOD) of 0.01 mg L-1 obtained for MET and RAN, were similar a...