The antigenotoxic activity of latex from Himatanthus articulatus

Himatanthus articulatus (Vahl) Woodson (Apocynaceae) is a native plant to the Amazon popularly used to treat ulcers, tumors, inflammations, cancer, syphilis and malaria. The aim of the present study was to investigate the in vivo genotoxic/antigenotoxic and mutagenic potential of this plant, using the comet and the micronucleus assays in mice. Female and male adult mice were treated with different doses of H. articulatus latex by gavage for two consecutive days. For the experiments, the latex was serially diluted with water to 1:2 (D1); 1:4 (D½) and 1:8 (D¼) and administered to the animals. ...