SÍNTESE E CARACTERIZAÇÃO DE NITROSIL COMPLEXOS COM AÇÃO ANTIBACTERIANA FRENTE A Pseudomonas aeruginosa

The compounds nitrosyl cis-[Ru(bpy)(phen)TU(NO)](PF6)3 (compound 1) and cis-[Ru(bpy)(phen)(4-N-Imd)(NO)](PF6)3 (compound 2) (bpy = 2,2’-bipyridine, phen = 1,10’-phenanthroline, TU = thiourea and 4-N-Imd = 4-nitroimidazole) were synthesized and characterized by UV-visible, infrared spectroscopies and electrochemical techniques. In the study of the reactivity it was possible to verify the nitric oxide labilization by square wave voltammetry and a photochemical upon blue light irradiation. This feature is very important for a potential application in phototherapy. Additionally, the antibacter...