Self-Assembled Nanoparticles of Diruthenium(II,III)-Ibuprofen Anticancer Metallodrug

The diruthenium(II,III)-ibuprofen (RuIbp) metallodrug shows anticancer activity in vitro and in vivo. The encapsulation into lipid nanoparticles enhanced the efficacy in glioblastoma, breast and prostate cancer cells. Here we report data for RuIbp hydrophobicity, solubility in alcohol/water, and behavior in 1-5% ethanol/water and ethanol/cell culture medium. RuIbp is capable of spontaneously generate self-assembled RuIbpNP nanoparticles when drug ethanolic solutions are added to water or cell growth culture medium at 1-5% ethanol. The phenomenon was investigated, and the nanoparticles characte...