Oncologia Ocular no Brasil: Qual o nosso passado, presente e futuro?

This study proposes a procedure for speciation of antimony by hydride generation atomic absorption spectrometry in pentavalent antimony drugs. The SbIII content was determined by selective generation of SbH3 in medium with higher SbV concentration using 4 to 20-fold lower citric acid solutions than recommended in the available literature. The multivariate optimization of the methods was performed through factorial design followed by a central composite design (CCD). The limit of detection (LOD) and limit of quantification (LOQ) were calculated at 0.15 and 0.05 µg L-1 and 0.48 and 0.17 µg L-1...