NEW APPLICATIONS FOR AMOXICILLIN DETERMINATION IN PURE FORM AND PHARMACEUTICALS BASED ON IODATE-IODIDE MIXTURE: TITRIMETRY AND SPECTROSCOPY STUDIES

Three simple methods are described for the determination of amoxicillin (AMX) in bulk drug and dosage forms using iodate-iodide mixture reagent. These methods employed the well-known analytical reaction between iodate-iodide mixture in the presence of acid solution. The iodide oxidized by iodate to iodine in an amount equivalent to the -COOH group present in amoxicillin (AMX) and the liberated iodine determined by titrimetry and spectrophotometry. In the titrimetric method (method A), the liberated iodine was reacted with a measured excess of thiosulphate and the residual thiosulphate was dete...