Nanostructured polymeric system based of cashew gum for oral admnistration of insulin

ABSTRACT The subcutaneous administration of insulin has been the treatment of millions of diabetics in the world. However, for such via insulin is invasive and not mimics the physiological action causing side effects. The oral route would be the most physiological and comfortable option, but the oral bioavailability of insulin is low by proteolytic activity and reduced permeability of the gastrointestinal tract. The aim of the study was to develop a nanostructured system integrating biomaterials for oral insulin delivery. Cashew gum (CG) is a polysaccharide extracted from the exudate of the pl...