Modeling the Local Viscoelastic Behavior of Living Cells Under Nanoindentation Tests

Abstract Aiming at multiscale numerical investigations of fibrous connective tissues, the present work proposes a finite strain viscoelastic model suitable to represent the local mechanical response of living cells in conjunction with finite element simulations of nanoindentation tests. The material model is formulated in a thermodynamically consistent framework based on a variational constitutive approach. As a case of study, a numerical investigation of the local compressible response of fibroblast cells is addressed. Moreover, a set of cyclic, stress relaxation and creep experiments are sim...