Método extendido de Hildebrand en la predicción de la solubilidad del ketoprofeno en mezclas cosolventes etanol + agua

Extended Hildebrand Solubility Approach (EHSA) developed by Martin et al. was applied to evaluate the solubility of ketoprofen (KTP) in ethanol + water cosolvent mixtures at 298.15 K. Calculated values of molar volume and solubility parameter for KTP were used. A good predictive capacity of EHSA was found by using a regular polynomial model in order five to correlate the W interaction parameter and the solubility parameters of cosolvent mixtures (δmix). Nevertheless, the deviations obtained in the estimated solubilities with respect to the experimental solubilities were on the same order like...

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