Integrative Approach Based on Simplex-Centroid Design, ESI-MS and Chemometric Analysis for Comprehensive Characterization of Phenolic Compounds from Endopleura uchi Bark

Endopleura uchi (Huber) Cuatrec. is an Amazonian medicinal plant with restricted distribution to the North Region of Brazil. Its bark is commonly used as natural medicines for the treatment of many diseases. Although widely investigated from the phytochemical viewpoint, the knowledge regarding the phenolic content remains unexplored. In order to access the phenolic composition of E. uchi bark, an integrative approach based on simplex-centroid design, direct infusion electrospray ionization mass spectrometry (ESI-MS) and chemometric analysis was adopted. In addition, the extracts were evaluated...