Determination of Aspirin Using Chemiluminescence System of Tris(1,10 phenanthroline)Ruthenium(II)-Cerium(IV)

A new chemiluminescence (CL) method has been proposed for the simple determination of aspirin (acetylsalicylic acid, ASA). The method is based on the enhancement effect of ASA in the CL reaction of tris(1,10 phenanthroline)ruthenium(II), Ru(phen)32+, with cerium(IV) (CeIV) in acidic medium. Under optimum conditions, the CL intensity was proportional to the concentration of the drug in solution over the range 0.72-72.00 µg mL-1 ASA. The limit of detection (S/N = 3) was 0.45 µg mL-1. In the method proposed, limit of detection was at least 30 times lower than the therapeutic concentration of AS...