COMPOSIÇÃO QUÍMICA E ATIVIDADE ANTILEISHMANIA DE Tocoyena hispidula

Phytochemical investigation of the CHCl3 fraction from EtOH extract of Tocoyena hispidula (Rubiaceae) stem resulted in the isolation and identification of D-(+)-mannitol, lupenone, 3-O-acetyloleanolic acid, lapachol, dimethyl chelidonate, morindolide and four mixtures (M1-M4): M1 (palmitate, margarate, linoleate, oleate e stearate of the multiflorenyl, lupeyl, sitosteryl and stigmasteryl), M2 (lupeol, taraxerol, germanicol, β-amyrin and E-fitol), M3 (campesterol, campestanol, stigmasterol, Δ22-stigmastenol, sitosterol and sitostanol) and M4 (7-ketositosterol and 7-ketostigmasterol). Structur...