Tempol
Mostrando 13-24 de 32 artigos, teses e dissertações.
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13. Sex differences in angiotensin II- induced hypertension
Sex differences in the development of hypertension and cardiovascular disease have been described in humans and in animal models. In this paper we will review some of our studies which have as their emphasis the examination of the role of sex differences and sex steroids in modulating the central actions of angiotensin II (ANG II) via interactions with free
Brazilian Journal of Medical and Biological Research. Publicado em: 26/03/2007
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14. Antioxidant Activity of Plant Extracts from Brazilian Flora: Study of Electron Paramagnetic Resonance (EPR) and Density Functional Theory (DFT). / Atividade antioxidante de extratos vegetais da flora brasileira: estudo com ressonância paramagnética eletrônica (RPE) e teoria do funcional da densidade (TFD)
There is, in Brazil, a great diversity of vegetable species, and a popular knowledge of several medicinal properties of the some of them. In studies carried out with plants? extracts, there is special interest in antioxidant activities. This work, focused in antioxidant activity, is divided in two parts: the first uses EPR technique to study the antioxidant
Publicado em: 2006
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15. ANGIOTENSINA II INTRA-RENAL MODULA A EXPRESSÃO DA ÓXIDO NÍTRICO SINTASE NEURONAL NA HIPERTENSÃO RENOVASCULAR 2R1C
Em condições fisiológicas, o óxido nítrico (NO) produzido principalmente pela óxido nítrico sintase neuronal (nNOS) exerce uma influência modulatória no fluxo sanguíneo renal. Ainda que alguns estudos demonstrem que a expressão de RNAm da nNOS renal está alterada durante a hipertensão arterial (HA), ainda não é bem conhecido como a expressão
Publicado em: 2005
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16. Papel do peroxinitrito na atividade leishmanicida de macrófagos em modelos murinos / Role of peroxynitrite in macrophage leishmanicidal activity in murine models
Os mecanismos oxidativos pelos quais macrófagos exercem atividade microbicida permanecem em discussão, e estudos com hospedeiros animais serão essenciais para elucidar tal questão. Nesse trabalho, estudamos os mecanismos microbicidas de macrófagos in vivo comparando parâmetros de infecção nas lesões de camundongos resistentes (C57Bl/6) e suscetívei
Publicado em: 2003
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17. Aging impairs flow-induced dilation in coronary arterioles: role of NO and H2O2
Aging contributes significantly to the development of cardiovascular disease and is associated with elevated production of reactive oxygen species (ROS). The beneficial effects of nitric oxide (NO)-mediated vasodilation are quickly abolished in the presence of ROS, and this effect may be augmented with aging. We previously demonstrated an age-induced impairm
American Physiological Society.
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18. Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles
Reduced availability of tetrahydrobiopterin (BH4) contributes to the age-related decline of nitric oxide (NO)-mediated vasodilatation of soleus muscle arterioles. Depending on availability of substrate and/or necessary co-factors, endothelial nitric oxide synthase (eNOS) can generate NO and/or superoxide (O2−). We evaluated the effects of age and chronic e
Blackwell Science Inc.
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19. PPAR-γ agonist rosiglitazone reverses increased cerebral venous hydraulic conductivity during hypertension
Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists have been shown to protect the cerebral vasculature, including the blood-brain barrier. In the present study, we investigated the effect of the PPAR-γ agonist rosiglitazone on changes in venous permeability during chronic hypertension induced by nitric oxide synthase inhibition. Female Sprague
American Physiological Society.
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20. Integration of skeletal muscle resistance arteriolar reactivity for perfusion responses in the metabolic syndrome
Previous study suggests that with evolution of the metabolic syndrome, patterns of arteriolar reactivity are profoundly altered and may constrain functional hyperemia. This study investigated interactions between parameters of vascular reactivity at two levels of resistance arterioles in obese Zucker rats (OZR), translating these observations into perfusion
American Physiological Society.
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21. Inhibition of natriuretic factors increases blood pressure in rats
Renal dopamine and nitric oxide contribute to natriuresis during high-salt intake which maintains sodium and blood pressure homeostasis. We wanted to determine whether concurrent inhibition of these natriuretic factors increases blood pressure during high-sodium intake. Male Sprague-Dawley rats were divided into the following groups: 1) vehicle (V)-tap water
American Physiological Society.
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22. PP2B-dependent NO production in the medullary thick ascending limb during diabetes
Calcineurin (PP2B) has recently been shown to be upregulated in the medullary thick ascending limb (mTAL) during diabetes. The mTAL expresses all three isoforms of nitric oxide synthase (NOS), which are subject to phosphoregulation and represent substrates for PP2B. Therefore, we hypothesized that diabetes induces PP2B-dependent upregulation of NOS activity
American Physiological Society.
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23. Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: Chemoprevention strategies with antioxidants
Modulation of the cytotoxicity and mutagenicity of 4-hydroxyestradiol (4-OHE2), an oxidative metabolite of estrogen, by antioxidants was assessed in human MCF7 cells and TK-6 lymphoblast cells. The cytotoxicity of the catecholic estrogens was potentiated by depletion of intracellular glutathione and was independent of oxygen concentration. Agents such as the
The National Academy of Sciences.
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24. Probing protein structure by solvent perturbation of NMR spectra: the surface accessibility of bovine pancreatic trypsin inhibitor.
In the absence of specific interactions, the relative attenuation of protein NMR signals due to added stable free radicals such as TEMPOL should reflect the solvent accessibility of the molecular surface. The quantitative correlation between observed attenuation and surface accessibility was investigated with a model system, i.e., the small protein bovine pa