Tcf Transcription Factors
Mostrando 1-12 de 76 artigos, teses e dissertações.
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1. Replication of TCF7L2 rs7903146 association with type 2 diabetes in an Iranian population
The transcription factor 7-like 2 gene (TCF7L2) rs7903146 T allele is constantly associated with Type 2 diabetes in various populations and ethnic groups. Nevertheless, this has not been observed in two studies involving Arab populations. The aim of the present study was to investigate the association between TCF7L2 rs7903146 in an Iranian population. Type 2
Genetics and Molecular Biology. Publicado em: 25/06/2010
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2. TCF7L2 gene rs7903146 polymorphism role in the brazilian population e its application in type 2 diabetes risk prediction / Papel do polimorfismo rs7903146 do gene TCF7L2 na população brasileira e sua aplicação na predição de risco de diabetes tipo 2
Os polimorfismos do gene TCF7L2 têm sido fortemente associados com risco de desenvolvimento de diabetes mellitus em populações de diversas origens étnicas. No presente estudo, investigou-se se esta associação se confirma em diferentes populações brasileiras e qual seu efeito sobre o desempenho de um modelo de predição de risco de diabetes mellitus
Publicado em: 2009
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3. T-Cell Factor 4N (TCF-4N), a Novel Isoform of Mouse TCF-4, Synergizes with β-Catenin To Coactivate C/EBPα and Steroidogenic Factor 1 Transcription Factors
We have cloned T-cell factor 4N (TCF-4N), an alternative isoform of TCF-4, from developing pituitary and 3T3-L1 preadipocytes. This protein contains the N-terminal interaction domain for β-catenin but lacks the DNA binding domain. While TCF-4N inhibited coactivation by β-catenin of a TCF/lymphoid-enhancing factor (LEF)-dependent promoter, TCF-4N potentiate
American Society for Microbiology.
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4. All Tcf HMG box transcription factors interact with Groucho-related co-repressors
Tcf/Lef family transcription factors are the downstream effectors of the Wingless/Wnt signal transduction pathway. Upon Wingless/Wnt signalling, β-catenin translocates to the nucleus, interacts with Tcf (1–3) and thus activates transcription of target genes (4,5). Tcf factors also interact with members of the Groucho (Grg/TLE) family of transcriptio
Oxford University Press.
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5. HMG box transcription factor TCF-4’s interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells
Members of the Tcf/Lef family of the HMG box transcription factors are nuclear effectors of the Wnt signal transduction pathway. Upon Wnt signaling, TCF/LEF proteins interact with β-catenin and activate transcription of target genes, while, in the absence of the Wnt signal, TCFs function as transcriptional repressors. All vertebrate Tcf/Lef transcription fa
Oxford University Press.
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6. Two Members of the Tcf Family Implicated in Wnt/β-Catenin Signaling during Embryogenesis in the Mouse
Tcf transcription factors interact with β-catenin and Armadillo to mediate Wnt/Wingless signaling. We now report the characterization of genes encoding two murine members of the Tcf family, mTcf-3 and mTcf-4. mTcf-3 mRNA is ubiquitously present in embryonic day 6.5 (E6.5) mouse embryos but gradually disappears over the next 3 to 4 days. mTcf-4 expression oc
American Society for Microbiology.
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7. Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein
Wnt signaling has an important role in both embryonic development and tumorigenesis. β-Catenin, a key component of the Wnt signaling pathway, interacts with the TCF/LEF family of transcription factors and activates transcription of Wnt target genes. Here, we identify a novel β-catenin-interacting protein, ICAT, that was found to inhibit the interaction of
Cold Spring Harbor Laboratory Press.
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8. Two distinct factors bind to the rabbit uteroglobin TATA-box region and are required for efficient transcription.
The rabbit uteroglobin gene is expressed in a variety of epithelial cell types like the lung Clara cells and the glandular and luminal epithelial cells of the endometrium. Expression in Clara cells is on a high constitutive level, whereas expression in the rabbit endometrium is under tight hormonal control. One important element of the rabbit uteroglobin gen
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9. Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
Lymphoid enhancer factor/T-cell factor (LEF/TCF) are transcription factors that mediate the Wnt signaling pathway, and have crucial roles during embryonic development in various organisms. Here we report that acetylation enhances nuclear retention of POP-1, the Caenorhabditis elegans LEF/TCF homolog, through increasing nuclear import and blocking nuclear exp
Cold Spring Harbor Laboratory Press.
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10. Hindgut defects and transformation of the gastro-intestinal tract in Tcf4−/−/Tcf1−/− embryos
Wnt signalling plays a critical role in both initiating and patterning of the anterior–posterior axis during development. Wnts exert their biological effects, in part, by activating specific target genes through members of the TCF/LEF family of transcription factors. To gain new insight into the role of T-cell factors (or Tcf's) during development, we anal
Nature Publishing Group.
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11. Serum-regulated transcription by serum response factor (SRF): a novel role for the DNA binding domain.
The transcription factors Serum Response Factor (SRF) and Ternary Complex Factor (TCF) form a ternary complex at the c-fos Serum Response Element (SRE). We show that in NIH3T3 cells TCF binding is required for regulated transcription in response to stimulation by phorbol myristate acetate (PMA), but not by whole serum. We constructed a novel transcriptionall
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12. Regulation of TCF ETS-domain transcription factors by helix–loop–helix motifs
DNA binding by the ternary complex factor (TCF) subfamily of ETS-domain transcription factors is tightly regulated by intramolecular and intermolecular interactions. The helix–loop–helix (HLH)-containing Id proteins are trans-acting negative regulators of DNA binding by the TCFs. In the TCF, SAP-2/Net/ERP, intramolecular inhibition of DNA binding is prom
Oxford University Press.