Tamoxifen
Mostrando 1-12 de 198 artigos, teses e dissertações.
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1. Immunohistochemical assessment of symptomatic postmenopausal endometrial polyps in tamoxifen users and nonusers: a case control study
ABSTRACT BACKGROUND: Endometrial polyps are common in postmenopausal women, and the effect of tamoxifen use (a risk factor for endometrial polyps) on their pathogenesis is unclear. OBJECTIVES: To evaluate the expression of hormone receptors and markers for proliferation/apoptosis (Ki-67 and Bcl-2) in endometrial polyps in postmenopausal users and nonuser
Sao Paulo Med. J.. Publicado em: 2020-02
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2. Pharmacogenetic testing in oncology: a Brazilian perspective
Pharmacogenetics, a major component of individualized or precision medicine, relies on human genetic diversity. The remarkable developments in sequencing technologies have revealed that the number of genetic variants modulating drug action is much higher than previously thought and that a true personalized prediction of drug response requires attention to ra
Clinics. Publicado em: 11/10/2018
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3. Agonistic activity of tamoxifen, a selective estrogen-receptor modulator (SERM), on arthritic ovariectomized mice
Arthritis is positively associated with the decline of sex hormones, especially estrogen. Tamoxifen (TMX) is a selective estrogen receptor modulator, possessing agonist or antagonistic activity in different tissues. Thus, the objective of this study was to investigate the effect of TMX on the zymosan-induced arthritis model. Female Swiss normal and ovariecto
Braz J Med Biol Res. Publicado em: 13/11/2017
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4. Analysis of the Ki-67 index in the vaginal epithelium of castrated rats treated with tamoxifen
OBJECTIVES: Vaginal atrophy and breast cancer are common conditions in postmenopausal women and tamoxifen is the standard endocrine treatment for hormone-sensitive tumors. The present study aimed to assess the effect of tamoxifen on Ki-67 protein expression in the vaginal epithelium of castrated rats. MATERIAL AND METHODS: Forty Wistar-Hannover adult, virg
Clinics. Publicado em: 2016-02
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5. Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites
This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological
Mem. Inst. Oswaldo Cruz. Publicado em: 24/11/2015
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6. Hormone therapy with tamoxifen reduces plasma levels of NT-B-type natriuretic peptide but does not change ventricular ejection fraction after chemotherapy in women with breast cancer
The objective of this study was to evaluate the effect of tamoxifen on the plasma concentration of NT-pro-B-type natriuretic peptide (NT-proBNP) in women undergoing chemotherapy for breast cancer and to correlate changes in NT-proBNP with the left ventricular ejection fraction (LVEF). Over a period of 12 months, we followed 60 women with a diagnosis of breas
Braz J Med Biol Res. Publicado em: 21/11/2014
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7. Determination of CYP2D6 *3, *4, and *10 frequency in women with breast cancer in São Luís, Brazil, and its association with prognostic factors and disease-free survival
The CYP2D6 enzyme is crucial for the metabolism of tamoxifen. The CYP2D6 gene is highly polymorphic, and individuals can be extensive, intermediate, or poor tamoxifen metabolizers. The aim of this study was to determine the frequencies of the CYP2D6 *3, *4, and *10 alleles in women with breast cancer who were treated with tamoxifen and analyze the associatio
Braz J Med Biol Res. Publicado em: 05/09/2014
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8. Effect of tamoxifen in RAFT miniemulsion polymerization during the synthesis of polymer nanoparticles
Tamoxifen (TXF) is currently the only hormonal agent used for treatment of breast cancer. Although very effective, TXF presents low solubility in water, which affects its absorption and bioavailability. A common strategy to overcome this barrier is the formulation of a drug delivery system (DDS) in order to increase the drug stability and improve the treatme
Polímeros. Publicado em: 27/05/2014
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9. Tamoxifen decreases the myofibroblast count in the healing bile duct tissue of pigs
OBJECTIVE: The aim of this study was to evaluate the effect of oral tamoxifen treatment on the number of myofibroblasts present during the healing process after experimental bile duct injury. METHODS: The sample consisted of 16 pigs that were divided into two groups (the control and study groups). Incisions and suturing of the bile ducts were performed in th
Clinics. Publicado em: 2013-01
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10. Estrogen and progesterone receptors in endometrial polyps of women exposed and not exposed to tamoxifen and in atrophic endometrium / Receptores de estrógeno e progesterona em pólipos endometriais de usuárias e não usuárias de tamoxifeno e no endométrio atrófico
Introduction: Tamoxifen has been used for the treatment of strogen receptor-positive breast cancer. The effect of tamoxifen in breast cancer is the it inhibition cancer cell growth by competitive antagonism with strogen for strogen receptor (ER). The mechanism of action of tamoxifen in this receptor varies among different tissues, with antagonist effect (e.g
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 17/02/2012
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11. Estudo farmacogenético do metabolismo do tamoxifeno : avaliação genotípica e fenotípica da CYP2D6
Introdução: As variações da CYP2D6 estão associadas com o desfecho clínico das pacientes na terapia adjuvante do câncer de mama com tamoxifeno (TAM). Esta associação deve-se principalmente a hidroxilação do N-desmetiltamoxifeno (NDT) pela CYP2D6 a endoxifeno (EDF) que, por sua alta potência antiestrogênica, é o principal responsável pela efic�
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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12. Caracterização da atividade de tamoxifeno no tratamento da leishmaniose experimental e investigação sobre seus mecanismos de ação. / Activity of tamoxifen in the treatment of experimental leishmaniasis and investigation on its mechanisms of action.
O tratamento de indivíduos que apresentam leishmaniose, seja ela cutânea ou visceral, é usualmente problemático, uma vez que os medicamentos utilizados na prática clínica são altamente tóxicos, requerem administração parenteral e nem sempre promovem a cura dos pacientes. Torna-se clara, portanto, a necessidade de se pesquisar novos fármacos com po
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/06/2011