Sulindac Metabolites
Mostrando 1-2 de 2 artigos, teses e dissertações.
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1. Study of the toxicity induced by the anti-inflammatory sulindac and its metabolites, sulindac sulfone and sulindac sulfide / Estudo da toxicidade induzida pelo antiinflamatório sulindaco e seus metabólitos sulfona e sulfeto
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) known to inhibit non-selectively ciclooxygenases (COX) 1 and 2. Sulindac is therapeutically used as anti-inflammatory and analgesic in the symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, and ankylosing spondylits. In addition to this property, a role in the prevention/
Publicado em: 2006
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2. Sulindac Metabolism and Synergy with Tumor Necrosis Factor-α in a Drug-Inflammation Interaction Model of Idiosyncratic Liver Injury
Sulindac (SLD) is a nonsteroidal anti-inflammatory drug (NSAID) that has been associated with a greater incidence of idiosyncratic hepatotoxicity in human patients than other NSAIDs. In previous studies, cotreatment of rats with SLD and a modestly inflammatory dose of lipopolysaccharide (LPS) led to liver injury, whereas neither SLD nor LPS alone caused live
The American Society for Pharmacology and Experimental Therapeutics.