Substitution Trials
Mostrando 1-12 de 31 artigos, teses e dissertações.
-
1. The tale of lenalidomide clinical superiority over thalidomide and regulatory and cost-effectiveness issues
Resumo A Agência Nacional de Vigilância Sanitária (ANVISA) aprovou em abril de 2017 a lenalidomida (LEN) para o mieloma múltiplo (MM) e síndrome mielodisplásica. A ANVISA havia negado o registro em 2010, e indeferido um recurso apresentado em 2012. O motivo do indeferimento foi a falta de estudos comparativos de efetividade demonstrando que LEN era mai
Ciênc. saúde coletiva. Publicado em: 26/09/2019
-
2. Reduced dietary salt for the prevention of cardiovascular disease
BACKGROUND: This is an update of a Cochrane review that was first published in 2011 of the effects of reducing dietary salt intake, through advice to reduce salt intake or low-sodium salt substitution, on mortality and cardiovascular events.OBJECTIVES: 1. To assess the long-term effects of advice and salt substitution, aimed at reducing dietary salt, on mort
Sao Paulo Med. J.. Publicado em: 2015-06
-
3. Evaluation of babassu meal in feed for layer hens during the growth phase
Studies were conducted to evaluate the nutritional value and inclusion levels of babassu meal (BM) in the diet of grower layer pullets in substitution to wheat meal. Digestibility, metabolism and growth trials were conducted. Twelve cecectomized roosters were used in the digestibility assay to determine the coefficients of standardized digestibility of amino
Rev. Bras. Cienc. Avic.. Publicado em: 2014-06
-
4. Sequence polymorphisms in Pvs48/45 and Pvs47 gametocyte and gamete surface proteins in Plasmodium vivax isolated in Korea
Nucleotide sequence analyses of the Pvs48/45 and Pvs47 genes were conducted in 46 malaria patients from the Republic of Korea (ROK) (n = 40) and returning travellers from India (n = 3) and Indonesia (n = 3). The domain structures, which were based on cysteine residue position and secondary protein structure, were similar between Plasmodium vivax (Pvs48/45 a
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-05
-
5. Planejamento de inibidores baseado em fragmentos moleculares para a enzima gliceraldeído-3-fosfato desidrogenase de Trypanosoma cruzi / Design of inhibitors through fragment-based drug discovery for the enzyme glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi
Chagas disease is a parasitic illness endemic in Latin America caused by the trypanosomatid parasite Trypanosoma cruzi that spreads around the world due to people migration. Nowadays, Benznidazole and Nifurtimox (banned in Brazil), are used for the treatment of this disease but causes severe side effects to patients. Recently, three new molecules have reache
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/04/2012
-
6. 2-Bromo-1,4-naphthoquinone: a potentially improved substitute of menadione in Apatone™ therapy
Apatone™, a combination of menadione (2-methyl-1,4-naphthoquinone, VK3) and ascorbic acid (vitamin C, VC) is a new strategy for cancer treatment. Part of its effect on tumor cells is related to the cellular pro-oxidative imbalance provoked by the generation of hydrogen peroxide (H2O2) through naphthoquinone redox cycling. In this study, we attempted to fin
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-08
-
7. Interferencia interespecifica entre amaranthus hybridus L. e amaranthus viridus L.
O objetivo deste trabalho foi estudar a interferencia interespecifica entre duas especies de Amaranthus - A. viridis e A. hybridus -, esta ultima com dois biotipos distintos (verde e roxo); ambas ocorriam associadas em dois locais. Nas populacoes de cada local foram feitos ensaios de substituicao independentes, em vasos, nos quais observou-se que as populaco
Pesquisa Agropecuaria Brasileira. Publicado em: 2011
-
8. Evaluation of alternative ingredients in diets of broilers with the addition of enzymes / Avaliação de ingredientes alternativos na alimentação de frangos de corte com a adição de enzimas
Two experiments were conduced to evaluate the inclusion of alternative ingredients, sunflower meal and sorghum, in diet of broilers with the addition of enzymes. The experiments were divided into three independent trials, which corresponded to each phase of raising: initial phase (1 21 days), where the performance characteristics were evaluated; growing phas
Publicado em: 2009
-
9. Polpa cítrica úmida despectinada em substituição à polpa peletizada no desempenho de bovinos de corte confinados / Despectinated moist citrus pulp in partial replacing of pelleted citrus pulp on beef cattle performance
The objective of this study was evaluate despectinated citrus pulp (Braspolpa®) replacing 30% of pelleted citrus pulp in feedlot beef cattle finishing diets. In the first trial, was used despectinated citrus pulp in natura. Forty eight yearling bulls (24 Nelore and 24 Canchim), 18 months old and averaging 404 and 439 kg initial live weight for Nelore and Ca
Publicado em: 2008
-
10. Valores de energia metabolizÃvel de alguns subprodutos da agroindustria e sua utilizaÃÃo na alimentaÃÃo de frangos de corte / Values of energy metabolizÃvel of some of agroindustria by-products and their use in food for cutting of broilers
Two different studies were conducted in order to develop the present work. In the first, the objective was to determine the values of apparent metabolizable energy (AME) and nitrogen corrected apparent metabolizable energy (AMEn) of coconut meal (CM), cashew nut meal (CNM) and two types of sugar cane yeast (SCY1 and SCY2) for chicks and roosters. Two metabol
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/03/2007
-
11. Detecção precoce de bactérias periodontopatogênicas e a ação de um gel de metronidazol 25% em crianças com Diabetes mellitus tipo I / Early detection of periodontopathogenic bacteria and the effect of a topic metronidazole 25% gel in children with type I Diabetes mellitus
Type I Diabetes mellitus (IDDM) is a metabolic disease characterized by deficiency on the insulin production, causing great systemic alterations, including at the oral cavity. Periodontal disease is more aggressive in diabetic patients, even during the childhood, and presents as etiological microorganisms the Aggregatibacter actinomycetemcomitans (A. actinom
Publicado em: 2007
-
12. Nutritional value of rice brans supplemented with phytase determined by different methodologies on birds / Valor nutricional de farelos de arroz suplementados com fitase, determinado por diferentes metodologias com aves
Most rations for birds is formulated on the basis of corn and soybean meal, feedstuffs of high cost. But, the use of non-conventional feeds will be able to make them more economical, since they do not affect negatively the performance of those animals. Five metabolism trials were conducted in the Poultry Production Sector of the Animal Science Department of
Publicado em: 2006