Substituent Pattern
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. Risk Factors for Mortality in Pediatric Cardiac Intensive Care Unit
The present study investigated the activity of pyrimidine derivatives against Aedes aegypti. Two compounds, 3c and 3d showed excellent larvicide activity. Additionally, quantitative structure-activity relationship (QSAR) models were built using multiple-linear regression and partial least squares with descriptors generated from Dragon and VolSurf+ software,
Int. J. Cardiovasc. Sci.. Publicado em: 2020-07
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2. Pyrimidine Derivatives: QSAR Studies of Larvicidal Activity against Aedes aegypti
The present study investigated the activity of pyrimidine derivatives against Aedes aegypti. Two compounds, 3c and 3d showed excellent larvicide activity. Additionally, quantitative structure-activity relationship (QSAR) models were built using multiple-linear regression and partial least squares with descriptors generated from Dragon and VolSurf+ software,
J. Braz. Chem. Soc.. Publicado em: 2020-07
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3. Caracterização eletroquímica e estudos mecânico-quânticos para obtenção de propriedades eletrônicas de parabenos / Electrochemical characterization and quantum-mechanical studies to obtain the eletronic properties of parabens
Os parabenos são conservantes antimicrobianos amplamente utilizados na indústria farmacêutica, cosmética e alimentícia. A cadeia alquílica, ligada ao grupo éster, define algumas características físico-químicas destes compostos, incluindo coeficiente de partição e propriedades redox. A voltametria e a análise computacional foram realizadas a fim
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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4. Caracterização eletroquímica e estudos mecânico-quânticos para obtenção de propriedades eletrônicas de parabenos / Electrochemical characterization and quantum-mechanical studies to obtain the eletronic properties of parabens
Os parabenos são conservantes antimicrobianos amplamente utilizados na indústria farmacêutica, cosmética e alimentícia. A cadeia alquílica, ligada ao grupo éster, define algumas características físico-químicas destes compostos, incluindo coeficiente de partição e propriedades redox. A voltametria e a análise computacional foram realizadas a fim
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2011
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5. Naturally occurring peptidoglycan variants of Streptococcus pneumoniae.
Analysis by high-performance liquid chromatography of the stem peptide composition of cell walls purified from a large number of pneumococcal strains indicates that these bacteria produce a highly conserved species-specific peptidoglycan independent of serotype, isolation date, and geographic origin. Characteristic features of this highly reproducible peptid
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6. Microbiological and Pharmacological Behavior of 7-Chlorolincomycin
Replacement of the 7-(R) hydroxyl group of lincomycin by a 7-chloro-substituent produced a compound with greater in vitro activity than the parent. Laboratory studies of this compound showed it to be highly active against all of the following strains of gram-positive organisms examined, including penicillinase- and nonpenicillinase-producing staphylococci, D
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7. Coenzymatic Activity of Pyridoxal 5′-Sulfate and Related Analogues of Pyridoxal 5′-Phosphate
The effect of changes in the substituent at the 5′-position of pyridoxal 5′-phosphate on the coenzymatic activity of six analogues of this coenzyme was determined for three bacterial enzymes. Pyridoxal 5′-sulfate showed substantial coenzymatic activity for arginine decarboxylase and tryptophanase, but not for D-serine dehydratase; α5-pyridoxalmethylph
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8. Proton nuclear magnetic resonance characterization of heme disorder in hemoproteins.
A proton NMR method is described for determining the orientation of a porphyrin within the heme pocket of a hemoprotein. The pattern of the hyperfine-shifted heme methyl resonances in low-spin ferric model compounds is demonstrated to characteristically reflect the position of a localized low-symmetry perturbation on the pi system. The specific assignments v
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9. DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells.
Nitrogen mustard alkylating agents react with isolated DNA in a sequence selective manner, and the substituent attached to the drug reactive group can impose a distinct sequence preference. It is not clear however to what extent the observed DNA sequence preferences are preserved in intact cells. The highly reiterated sequence of human alpha DNA has been use
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10. Conversion of chlorobiphenyls into phenylhexadienoates and benzoates by the enzymes of the upper pathway for polychlorobiphenyl degradation encoded by the bph locus of Pseudomonas sp. strain LB400.
Metabolism of 21 chlorobiphenyls by the enzymes of the upper biphenyl catabolic pathway encoded by the bph locus of Pseudomonas sp. strain LB400 was investigated by using recombinant strains harboring gene cassettes containing bphABC or bphABCD. The enzymes of the upper pathway were generally able to metabolize mono- and dichlorinated biphenyls but only part
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11. Structure-activity relationships of quinolone agents against mycobacteria: effect of structural modifications at the 8 position.
A series of quinolones with substitutions at the 8 position has been prepared as part of a study to examine the relationship between structural modifications at this position and activity against mycobacteria. The compounds were prepared by procedures described in the literature and were evaluated for their activities against Mycobacterium fortuitum and Myco
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12. Influence of alternative electron acceptors on the anaerobic biodegradability of chlorinated phenols and benzoic acids.
Nitrate, sulfate, and carbonate were used as electron acceptors to examine the anaerobic biodegradability of chlorinated aromatic compounds in estuarine and freshwater sediments. The respective denitrifying, sulfidogenic, and methanogenic enrichment cultures were established on each of the monochlorinated phenol and monochlorinated benzoic acid isomers, usin