Substantia Nigra
Mostrando 1-12 de 244 artigos, teses e dissertações.
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1. Association between BDNF G196A (Val66Met) polymorphism and cognitive impairment in patients with Parkinson's disease: a meta-analysis
Brain-derived neurotrophic factor (BDNF) is widely expressed in the central nervous system and prolongs the survival of dopaminergic neurons in the substantia nigra. Several studies have recently investigated the association between BDNF G196A (Val66Met), a single nucleotide polymorphism influencing cognitive processes, and cognitive impairment in Parkinson'
Braz J Med Biol Res. Publicado em: 29/07/2019
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2. Reinforcement omission effects in rats with bilateral lesions in the substantia nigra pars compacta and ventral tegmental area
Reinforcement omission effects (ROEs) are characterized by higher response rates after reinforcement omission than after reinforcement delivery. This pattern of behavior is interpreted in terms of motivational and attentional processes. Recent studies from our laboratory have shown that the amygdala, nucleus accumbens, and medial prefrontal cortex are involv
Braz J Med Biol Res. Publicado em: 10/07/2019
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3. Lafora e Trétiakoff: a denominação dos corpos de inclusão descobertos por Lewy
RESUMO Fritz Heinrich Jakob Lewy descreveu pela primeira vez, em 1912, inclusões singulares inéditas em neurônios de certos núcleos do cérebro em casos de Paralysis agitans e comparou seu achado aos corpos amilóides, como descrito por Lafora um ano antes. Gonzalo Rodriguez Lafora estudou um caso de Paralysis agitans, em 1913,e reconheceu, descreveu e r
Arq. Neuro-Psiquiatr.. Publicado em: 2017-10
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4. Antioxidant Activity of Oral Administration of Rosmarinus Officinalis Leaves Extract on Rat's Hippocampus which Exposed to 6-Hydroxydopamine
Carnosic acid, a diterpene of Rosemarinus officinalis leaves extract (RE), has potent antioxidant activity in vitro. The dopaminergic connection of substantia nigra pars compacta to the hippocampus might be affected by oxidative stress which caused cognitive impairment observed in the early phase of Parkinson's disease (PD). Adult male Wistar rats were lesio
Braz. arch. biol. technol.. Publicado em: 29/04/2016
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5. Schinus terebinthifolius administration prevented behavioral and biochemical alterations in a rotenone model of Parkinson's disease
ABSTRACT Parkinson's disease is a neurodegenerative disorder characterized by motor impairment, cognitive decline and psychiatric symptoms. Schinus terebinthifolius Raddi, Anacardiaceae, had been studied for its anti-inflammatory and antioxidant properties, and in this study, the stem bark was evaluated for the neuroprotective effects on behavioral and bioch
Rev. bras. farmacogn.. Publicado em: 2016-04
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6. Effect of adenosine A2A receptor antagonists on motor disorders induced by 6-hydroxydopamine in rat
PURPOSE: To investigate the role of adenosine A2A receptors on 6-OHDA-induced motor disorder in rat. METHODS: In order to induce experimental model of Parkinson's disease, 6-hydoxydopamine (8 μg/rat) was injected unilaterally into the SNc. After three weeks as a recovery period, 6-OHDA-induced bradykinesia and balance disturbances were assessed by using
Acta Cir. Bras.. Publicado em: 2016-02
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7. Neuroinflamação na patofisiologia da doença de Parkinson e evidências terapêuticas de drogas antiinflamatórias
A doença de Parkinson (DP) é a segunda doença neurodegenerativa mais comum afetando aproximadamente 1,6% da população acima de 60 anos de idade. Os sinais motores cardinais são o resultado da degeneração progressiva de neurônios dopaminérgicos da substantia nigra pars compacta (SNpc), a qual está intimamente envolvida com o controle motor. Atualme
Arq. Neuro-Psiquiatr.. Publicado em: 2015-07
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8. Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transc
Genet. Mol. Biol.. Publicado em: 2015-03
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9. Efeitos do envelhecimento sobre o sistema nitrérgico dos núcleos da base em humanos
Nitric oxide (NO) is a gaseous molecule that plays a role in a number of physiologic processes. The available evidence suggests that NO is a major neurotransmitter involved in motor control and emotion/behavior modulation. To investigate the distribution and morphology of the nitrergic system in human basal nuclei, we studied samples from the striatum, globu
Arq. Neuro-Psiquiatr.. Publicado em: 2014-10
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10. Hypoxic-ischemic injury decreases anxiety-like behavior in rats when associated with loss of tyrosine-hydroxylase immunoreactive neurons of the substantia nigra
Neonatal Sprague-Dawley rats were randomly divided into normal control, mild hypoxia-ischemia (HI), and severe HI groups (N = 10 in each group at each time) on postnatal day 7 (P7) to study the effect of mild and severe HI on anxiety-like behavior and the expression of tyrosine hydroxylase (TH) in the substantia nigra (SN). The mild and severe HI groups were
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-01
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11. Treadmill training in diabetic rats: effects on motor and sensitive behavior, tyrosine hydroxylase immunoreactivity in the substantia nigra, calcitonin gene-related peptide in the dorsal horn of the spinal cord and sural nerve morphology / Treinamento em esteira em ratos diabéticos : efeitos sobre o comportamento motor e sensorial, imunomarcação de tirosina hidroxilase na substância nigra, peptídeo relacionado ao gene da calcitonina no corno dorsal da medula espinal e morfologia do nervo sural
O objetivo desta tese foi analisar os efeitos do exercício físico sobre o comportamento motor, a expressão de tirosina hidroxilase na subtsância nigra, a sensibilidade mecânica e nociceptiva, a morfologia do nervo sural e a expressão de peptídeo relacionado ao gene da calcitonina no corno dorsal da medula espinal de ratos adultos machos e diabéticos
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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12. Caracterização da substância negra humana durante o envelhecimento / Caracterização da substância negra humana durante o envelhecimento
INTRODUÇÃO: A presença e extensão da perda neuronal no encéfalo dos idosos ainda é controversa. A substância negra (SN) é uma região localizada no mesencéfalo e caracterizada macroscopicamente pela coloração escura, devido à presença neuromelanina. O envelhecimento da SN ainda é um mistério, mas existem grandes quantidades de estudos relativo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/09/2011