Subcutaneous Route
Mostrando 1-12 de 150 artigos, teses e dissertações.
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1. Samsum ant venom modulates the immune response and redox status at the acute toxic dose in vivo
Abstract Background: Ant venoms express surface molecules that participate in antigen presentation involving pro- and anti-inflammatory cytokines. This work aims to investigate the expression of MHC-II, CD80 and CD86 on the polymorphonuclear cells (PMNs) in rats injected with samsum ant venom (SAV). Methods: Rats were divided into three groups - control,
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 02/12/2019
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2. Nanostructured polymeric system based of cashew gum for oral admnistration of insulin
ABSTRACT The subcutaneous administration of insulin has been the treatment of millions of diabetics in the world. However, for such via insulin is invasive and not mimics the physiological action causing side effects. The oral route would be the most physiological and comfortable option, but the oral bioavailability of insulin is low by proteolytic activity
Matéria (Rio J.). Publicado em: 16/09/2019
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3. Effect of S-methyl-l-thiocitrulline dihydrochloride on rat micturition reflex
ABSTRACT Objective: To evaluate the effect of neuronal nitric oxide synthase on the striated urethral sphincter and the urinary bladder. Materials and Methods: A coaxial catheter was implanted in the proximal urethra and another one in the bladder of female rats, which were anesthetized with subcutaneous injection of urethane. The urethral pressure with sa
Int. braz j urol.. Publicado em: 2016-10
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4. Copaiba oil effect under different pathways in mice subjected to sepsis
PURPOSE: To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture.METHODS:Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; Control group: submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with c
Acta Cir. Bras.. Publicado em: 2014-08
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5. The putative role of ovary removal and progesterone when considering the effect of formaldehyde exposure on lung inflammation induced by ovalbumin
OBJECTIVE: Formaldehyde exposure during the menstrual cycle is known to affect the course of allergic lung inflammation. Because our previous data demonstrated that formaldehyde combined with an ovariectomy reduced allergic lung inflammation, we investigated the putative role of ovary removal and progesterone treatment when considering the effect of formald
Clinics. Publicado em: 2013-12
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6. Sistemas de liberação de geleificação in situ para veiculação de siRNA: desenvolvimento, caracterização e estudos in vitro e in vivo em modelo animal / In situ gelling delivery systems for siRNA: development, characterization and studies in vitro and in vivo in animal model
A comprovação de que siRNA pode ser usado para supressão de genes em diferentes células de mamíferos atraiu grande atenção como nova possibilidade de tratamento para diversas doenças. No entanto, para aplicação terapêutica de siRNA é necessário o desenvolvimento de um sistema de liberação efetivo e não tóxico, que permita a captação celula
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2012
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7. Assessment of immunity against avian colibacillosis induced by an aroA mutant containing increased serum survival gene in broilers
Colibacillosis is an important disease in the poultry industry which causes serious economic damages. As it is suggested that vaccination is one of the means to control colibacillosis, we tried to investigate the vaccine potential of a ΔaroA derivative of an O78:K80 avian pathogenic Escherichia coli containing increased serum survival gene. 490 chicks were
Brazilian Journal of Microbiology. Publicado em: 2012-03
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8. Administração de antibióticos por via subcutânea: uma revisão integrativa da literatura / Administration of antibiotics by subcutaneous injection: integrative literature review
A administração de medicamentos por via subcutânea é considerada segura, de manuseio simples e descrita como alternativa às vias intravenosa e intramuscular em pacientes em cuidados paliativos (CP) com difícil acesso venoso. A escassez de estudos e a pouca divulgação dessa via parenteral para administração de antibióticos restringem o seu uso. Por
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/12/2011
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9. An experimental protocol for the establishment of dogs with long-term cellular immune reactions to Leishmania antigens
Domestic dogs are considered to be the main reservoirs of zoonotic visceral leishmaniasis. In this work, we evaluated a protocol to induce Leishmania infantum/Leishmania chagasi-specific cellular and humoral immune responses in dogs, which consisted of two injections of Leishmania promastigote lysate followed by a subcutaneous inoculation of viable promastig
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-03
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10. Preparação e caracterização de nanoparticulas com heparina e sua avaliação em modelo animal de trombose venosa / Preparation and characterization of heparin-loaded nanoparticles and its evaluation in animal model of venous thrombosis
Heparin is an anticoagulant widely used in the treatment and prophylaxis of deep vein thrombosis (DVT). Some limitations of its use is the cost and route of administration, intravenous or subcutaneous, sometimes in repeated doses in 24 hours. Thus, the development of a product that can be administered subcutaneously in a smaller number of applications or ora
Publicado em: 2010
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11. The adjuvant effect of the mesoporous nanostructurated SBA-15 silica in immunizations by the oral route. / Efeito adjuvante da sílica mesoporosa nanoestruturada SBA-15 na imunização pela via oral.
The nanostructured SBA-15 silica is a polymer that due to its physicochemical properties shows great potential as a mucosal adjuvant. Immunization by the oral route of mice with Hepatitis A vaccine or human gama globulin adsorbed/encapsulated in SBA-15 revealed increases in the IgG e IgA specific antibody titers and showed that this silica does not interfere
Publicado em: 2009
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12. Evaluation for leptospirosis vaccine. Relation between in vitro growh inibition test and potency test in hamsters / Avaliação de vacinas antileptospirose. Relação entre o teste de inibição de crescimento de leptospiras in vitro e o teste de desafio em hamsters
It was investigated the existence in hamsters of correlation between the standard potency test of bacterins antileptospires and the in vitro leptospires growth inhibition test. The assays were performed, in male hamsters, separately according to the commercial (A and B) animal antileptospirosis bacterin used. The quality of the bacterins and the level of neu
Publicado em: 2008