Strategy Formulation
Mostrando 13-24 de 140 artigos, teses e dissertações.
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13. Optimization of self-nanoemulsifying formulations for weakly basic lipophilic drugs: role of acidification and experimental design
ABSTRACT Formulators face great challenges in adopting systematic approaches for designing self-nanoemulsifying formulations (SNEFs) for different drug categories. In this study, we aimed to build-up an advanced SNEF development framework for weakly basic lipophilic drugs, such as cinnarizine (CN). First, the influence of formulation acidification on CN solu
Braz. J. Pharm. Sci.. Publicado em: 2016-12
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14. Antifungal efficacy of amphotericin B encapsulated fibrin microsphere for treating Cryptococcus neoformans infection in Swiss albino mice
Abstract A natural and biocompatible fibrin microsphere is one of the most promising dual delivery vehicle as compared to other traditionally designed delivery modalities. It represents sustained delivery of encapsulated drug and is easily biodegradable in the blood circulation. In the present study, we evaluated the systemic augmentation of the antifungal a
Braz J Infect Dis. Publicado em: 2016-08
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15. Multivariate study of Nile tilapia byproducts enriched with omega-3 and dried with different methods
Abstract The present work aimed at studying the effect of different drying methods applied to tilapia byproducts (heads, viscera and carcasses) fed with flaxseed, verifying the contents of omega-3 fatty acids. Two diets were given to the tilapia: a control and a flaxseed formulation, over the course of 60 days. After this period, they were slaughtered and th
Food Sci. Technol. Publicado em: 19/01/2016
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16. Beauveria Bassiana Applied to Broiler Chicken Houses as Biocontrol of Alphitobius Diaperinus Panzer (Coleoptera: Tenebrionidae), an Avian Pathogens Vector
ABSTRACT Beauveria bassiana is naturally found in broiler chicken houses, and has been shown to be active against the lesser mealworm, Alphitobius diaperinus. The effectiveness of soil application of B. bassiana in emulsifiable oil-type formulation (Unioeste 4 isolate) to control the lesser mealworm in commercial poultry house was evaluated. The fungus was a
Rev. Bras. Cienc. Avic.. Publicado em: 2015-12
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17. Use of organic compost produced from slaughterhouse waste as fertilizer in soybean and corn crops
Slaughterhouses generate large amounts of rumen content and its use as a fertilizer may offer an environmentally friendly strategy for its management. The effect of an organic fertilizer produced from slaughterhouse waste on the fertility of sandy and clayey soils as well as soybean yield (Glycine max L.) and corn (Zea mays L.) crops was evaluated. Field exp
Sci. agric. (Piracicaba, Braz.). Publicado em: 2015-08
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18. Using a single tablet daily to treat latent tuberculosis infection in Brazil: bioequivalence of two different isoniazid formulations (300 mg and 100 mg) demonstrated by a sensitive and rapid high-performance liquid chromatography-tandem mass spectrometry method in a randomised, crossover study
The recommended treatment for latent tuberculosis (TB) infection in adults is a daily dose of isoniazid (INH) 300 mg for six months. In Brazil, INH was formulated as 100 mg tablets. The treatment duration and the high pill burden compromised patient adherence to the treatment. The Brazilian National Programme for Tuberculosis requested a new 300 mg INH formu
Mem. Inst. Oswaldo Cruz. Publicado em: 02/06/2015
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19. Comparison of the safety and efficacy of a fixed-dose combination regimen and separate formulations for pulmonary tuberculosis treatment
OBJECTIVES: Fixed-dose combination formulations, which simplify the administration of drugs and prevent the development of drug resistance, have been recommended as a standard anti-tuberculosis treatment regimen. However, the composition and dosage recommendations for fixed-dose combination formulations differ from those for separate formulations. Thus, que
Clinics. Publicado em: 2015-06
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20. The Local Formulation for the Modified Green's Function Method
AbstractThe Modified Global Green's Function Method (MGGFM) is an integral technique that is characterized by good accuracy in the evaluation of boundary fluxes. This method uses only projections of the Green's Function for the solution of the discrete problem and this is the origin of the term 'Modified' of its name. In this paper the local strategy for cal
Lat. Am. j. solids struct.. Publicado em: 2015-05
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21. Optimal Placement of Piezoelectric Macro Fiber Composite Patches on Composite Plates for Vibration Suppression
AbstractThis work presents a new methodology for the parametric optimization of piezoelectric actuators installed in laminated composite structures, with the objective of controlling structural vibrations. Problem formulation is the optimum location of a Macro Fiber Composite (MFC) actuator patch by means the maximization of the controllability index. The co
Lat. Am. j. solids struct.. Publicado em: 2015-05
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22. Heterogeneity of Isomorphic Pressures: Intertwining the Resource-Based View and the Neoinstitutional Approach
The purpose of this research is to establish a conceptual framework that contributes to explaining sustained competitive advantage, forming an analytical framework that brings the resource-based view and organizational analysis' neoinstitutional approaches closer together. A detailed epistemological articulation has been undertaken to advance the understandi
BAR, Braz. Adm. Rev.. Publicado em: 2014-12
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23. An efficient formulation for linear and geometric non-linear membrane elements
Utilizing the straingradient notation process and the free formulation, an efficient way of constructing membrane elements will be proposed. This strategy can be utilized for linear and geometric non-linear problems. In the suggested formulation, the optimization constraints of insensitivity to distortion, rotational invariance and not having parasitic shear
Lat. Am. j. solids struct.. Publicado em: 2014-11
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24. State estimation of chemical engineering systems tending to multiple solutions
A well-evaluated state covariance matrix avoids error propagation due to divergence issues and, thereby, it is crucial for a successful state estimator design. In this paper we investigate the performance of the state covariance matrices used in three unconstrained Extended Kalman Filter (EKF) formulations and one constrained EKF formulation (CEKF). As bench
Braz. J. Chem. Eng.. Publicado em: 2014-09