Strategies With Derivatives
Mostrando 25-36 de 48 artigos, teses e dissertações.
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25. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
The modern approach to the development of new chemical entities against complex diseases, especially the neglected endemic diseases such as tuberculosis and malaria, is based on the use of defined molecular targets. Among the advantages, this approach allows (i) the search and identification of lead compounds with defined molecular mechanisms against a defin
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-10
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26. PLANEJADORES PARA TRANSPORTE EM POLIDUTOS / PIPELINE TRANSPORTATION PLANNERS
Pipelines have an important role in oil and its derivatives transportation, since they are the most effective way to transport high volumes through long distances. The motivation for this work is that a non negligible part of the final price for those products are due to transportation costs. Few authors have addressed this problem, with most of the previous
Publicado em: 2005
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27. Preparação de aminoacidos não proteinogenicos, estruturalmente relacionados ao adoçante natural Monatina
Monatin is a natural amino acid, which exhibits sweetener potency 1400 times bigger than glucose. When mixtured with other sweeteners this compound increases the taste and the flavor of some preparation. This feature increases the biological and commercial importance of Monatin. This amino acid has been isolated from the roots of the south African plant Schl
Publicado em: 2003
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28. Adição de nucleofilos a ions oxocarbenio ciclicos derivados de y-Lactois 5-Substituidos. Formação diastereosseletiva de sistemas tetraidrofuranicos 2,5-trans- e 2,5-cis-Dissubstituidos
2,5-Disubstituted tetrahydrofurans moieties are found in many biologically important natural products including pheromones, polyether antibiotics and acetogenins. We have demonstrated that the synthesis of 2,5-disubstituted tetrahydrofuran derivatives can be achieved in good yields and divergent diastereoselectivity either by intermolecular or intramolecular
Publicado em: 2001
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29. Investimento energetico em tempo de crise : o projeto gasoduto-termeletrica Bolivia-Mato Grosso do Sul-São Paulo- na conjuntura 1994-1996
This work aims to evaluate the recent situation and perspectives of offer and final use of natural gas (NG) in Brazil. At first, a discussion about the productive investiments in the industry is introduced, together with the most representative aspects of the productive system globalization process. Secondly, a compilation of the international market and inv
Publicado em: 1996
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30. Enzymes as reagents in peptide synthesis: enzyme-labile protection for carboxyl groups.
N-Benzyloxycarbonyl derivatives of isoglutamine and isoasparagine were coupled with arginine methyl ester through the action of dicyclohexylcarbodiimide. The resulting benzyloxycarbonyl derivatives of isoglutaminylarginine methyl ester and isoasparaginylarginine methyl ester were treated with trypsin for removal of the ester groups and then with porcine panc
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31. Evaluation of alternative strategies to optimize ketorolac transdermal delivery
In the present study, 2 alternative strategies to optimize ketorolac transdermal delivery, namely, prodrugs (polyoxyethylene glycol ester derivatives, I–IV) and nanostructured lipid carriers (NLC) were investigated. The synthesized prodrugs were chemically stable and easily degraded to the parent drug in human plasma. Ketorolac-loaded NLC with high drug co
Springer-Verlag.
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32. Antiviral therapy for human immunodeficiency virus infections.
Depending on the stage of their intervention with the viral replicative cycle, human immunodeficiency virus inhibitors could be divided into the following groups: (i) adsorption inhibitors (i.e., CD4 constructs, polysulfates, polysulfonates, polycarboxylates, and polyoxometalates), (ii) fusion inhibitors (i.e., plant lectins, succinylated or aconitylated alb
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33. Biodistribution of a Bispecific Single-chain Diabody and Its Half-life Extended Derivatives*
Small recombinant antibody molecules such as bispecific single-chain diabodies (scDb) possessing a molecular mass of ∼55 kDa are rapidly cleared from circulation. We have recently extended the plasma half-life of scDb applying various strategies including PEGylation, N-glycosylation and fusion to an albumin-binding domain (ABD) from streptococcal protein G
American Society for Biochemistry and Molecular Biology.
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34. Action of 1-isonicotinyl-2-palmitoyl hydrazine against the Mycobacterium avium complex and enhancement of its activity by m-fluorophenylalanine.
In the present work, we investigated whether resistance to isoniazid (INH) of organisms belonging to the Mycobacterium avium complex was caused by the bacterial cell envelope, with the cell wall and the outer layer acting as an exclusion barrier. We observed that this exclusion barrier was most efficient in excluding the hydrophilic drug INH, as this drug co
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35. Mutational analysis of essential IncP alpha plasmid transfer genes traF and traG and involvement of traF in phage sensitivity.
Although the broad-host-range IncP plasmids can vegetatively replicate in diverse gram-negative bacteria, the development of shuttle vector systems has established that the host range for IncP plasmid conjugative transfer is greater than the range of bacteria that sustain IncP replicons. Towards understanding IncP plasmid conjugation and the connection betwe
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36. Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups
Induction of phase 2 enzymes and elevations of glutathione are major and sufficient strategies for protecting mammals and their cells against the toxic and carcinogenic effects of electrophiles and reactive forms of oxygen. Inducers belong to nine chemical classes and have few common properties except for their ability to modify sulfhydryl groups by oxi
The National Academy of Sciences.