Sphingosine
Mostrando 1-12 de 147 artigos, teses e dissertações.
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1. Sphingosine Kinase 1 urothelial expression is increased in patients with neurogenic detrusor overactivity
Objectives: To evaluate the expression of sphingosine kinase 1 (SPK1) in the bladder wall in patients with neurogenic lower urinary tract dysfunction and its association with clinical, urodynamic and pathological features. Materials and Methods: The expression of SPK1 was studied in bladder wall specimens obtained from cystectomy using immunohistochemistry
Int. braz j urol.. Publicado em: 2015-12
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2. Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits
PURPOSE: To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH). METHODS: The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S
Acta Cir. Bras.. Publicado em: 2015-10
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3. CULTIVO IN SITU DE FOLÍCULOS OVARIANOS PRÉ-ANTRAIS DE CABRAS COM ESFINGOSINA (S1P) E FATOR INIBIDOR DA LEUCEMIA (LIF). / CULTURE IN SITU OF OVARIAN PREANTRAL FOLLICLE WITH SPHINGOSINE 1-PHOSPHATE (S1P) AND LEUKEMIA INHIBITORY FACTOR (LIF)
The manipulation of oocytes enclosed in follicles Ovarian Pre-Antral, allows increasing the reproductive potential of females from the isolation and cultivation. The follicular viability can be affected negatively correlated with age, malnutrition, exposure to radio or chemotherapy and health conditions. The alternatives are to use these research for develop
Publicado em: 2011
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4. Sintese de um analogo ciclico da esfingosina / Synthesis of sphingosine of sphingosine cyclic analogous
Sphingosine are natural compounds that bear multiple known biological activities. The sphingosine molecule is representative of this class of biological compounds. The present study is related to the synthesis of a new cyclic analogue of sphingosine. The first part of this dissertation was focused on the synthesis of the hydroxy lactol F. The synthesis began
Publicado em: 2008
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5. Effect of sphingosine and phorbol-12-myristate-13-acetate on the growth and dimethylsulfoxide-induced differentiation in the insect trypanosomatid Herpetomonas samuelpessoai
We investigated the effect of two modulators of protein kinase C, sphingosine and phorbol-12-myristate-13-acetate (PMA), on the growth and dimethylsulfoxide (DMSO)-induced differentiation in Herpetomonas samuelpessoai. Sphingosine did not stimulate the transformation of undifferentiated-promastigotes in differentiated-paramastigotes. PMA alone or in associat
Memórias do Instituto Oswaldo Cruz. Publicado em: 14/06/2007
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6. Heterogeneidade e mecanismos moleculares da atividade anti-apoptótica das subfrações de HDL em células endoteliais humanas / Heterogeneity and molecular mechanisms of anti-apoptotic activity of high-density lipoprotein (HDL) subfractions on endothelial cells
Introdução: A lipoproteína de baixa densidade (LDL) e suas formas oxidadas (LDLox) possuem múltiplas propriedades aterogênicas, atuando na deposição de colesterol, indução e manutenção da inflamação, disfunção endotelial, surgimento de células espumosas na parede arterial e conseqüente formação da placa de ateroma. Adicionalmente, LDLox in
Publicado em: 2007
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7. The Evaluation of the biomarker (sphinganine / sphingosine) of the intoxication for fumonisin in swine. / Avaliação do biomarcador (esfinganina / esfingosina) na intoxicação por fumonisinas em suínos.
Fumonisinas são m grupo de micotoxinas produzidas por espécies do gênero Fusarium, fungo de ampla distribuição mundial e com alta prevalência em grãos, principalmente no milho, que freqüentemente veiculam estas toxinas para subprodutos ou para alimentos destinados ao consumo humano e animal. As fumonisinas são inibidores específicos da síntese dos
Publicado em: 2005
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8. Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation
Sphingosine kinase 1 is an agonist-activated signalling enzyme that catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist-driven cellular responses, including stimulation of cell proliferation, inhibition of apoptosis and expression of inflammatory molecules. Although agonist-induced sti
Oxford University Press.
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9. Sphingosine: a mediator of acute renal tubular injury and subsequent cytoresistance.
The goal of this study was to determine whether sphingosine and ceramide, second messengers derived from sphingolipid breakdown, alter kidney proximal tubular cell viability and their adaptive responses to further damage. Adult human kidney proximal tubular (HK-2) cells were cultured for 0-20 hr in the presence or absence of sphingosine, sphingosine metaboli
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10. Early Activation of Sphingosine Kinase in Mast Cells and Recruitment to FcɛRI Are Mediated by Its Interaction with Lyn Kinase
Sphingosine kinase has been recognized as an essential signaling molecule that mediates the intracellular conversion of sphingosine to sphingosine-1-phosphate. In mast cells, induction of sphingosine kinase and generation of sphingosine-1-phosphate have been linked to the initial rise in Ca2+, released from internal stores, and to degranulation. These events
American Society for Microbiology.
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11. Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning
Aging hearts are known to have diminished capacity to be protected against reoxygenation ischemia/reperfusion (IR) injury provided by various cardioprotective regimens. In search of a more successful regimen, we have studied the response of aged hearts to preconditioning (PC) and postconditioning (POST) elicited by sphingosine or sphingosine 1-phosphate trea
Landes Bioscience.
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12. Sphingosine Kinase Regulates the Sensitivity of Dictyostelium discoideum Cells to the Anticancer Drug Cisplatin
The drug cisplatin is widely used to treat a number of tumor types. However, resistance to the drug, which remains poorly understood, limits its usefulness. Previous work using Dictyostelium discoideum as a model for studying drug resistance showed that mutants lacking sphingosine-1-phosphate (S-1-P) lyase, the enzyme that degrades S-1-P, had increased resis
American Society for Microbiology.