Spantide
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Involvement of NK-1 receptors of the basolateral and central nuclei of the amygdala in the defensive behavior of rats / Participação dos receptores NK-1 dos núcleos basolateral e central da amígdala no comportamento defensivo de ratos
A substantial body of evidence obtained in the last decade demonstrated that the Substance P (SP) is an important mediator of the affective and emotional behaviors. SP is a pro-aversive compound when microinjected within the dorsal periaqueductal gray (dPAG). These effects are mediated by the type 1 neurokininergic receptors (NK-1), since the defensive behav
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2012
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2. Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety
Electrical stimulation of midbrain tectum structures, particularly the dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), produces defensive responses, such as freezing and escape behavior. Freezing also ensues after termination of dPAG stimulation (post-stimulation freezing). These defensive reaction responses are critically mediated by γ-amin
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-04
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3. Envolvimento de receptores NK-1 e NK-3 no comportamento defensivo induzido pela estimulação elétrica da substância cinzenta periaquedutal dorsal / Involvement of NK-1 and NK-3 receptors on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray.
A substância cinzenta periaquedutal dorsal (SCPd) é considerada uma das principais estruturas do teto mesencefálico envolvida no substrato neural da aversão a estímulos proximais. GABA e 5-HT são apontados como neurotransmissores envolvidos na modulação das respostas defensivas elaboradas na SCPd. Recentemente, mecanismos neurocininérgicos também t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/10/2011
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4. In vitro and in vivo evaluation of topical formulations of Spantide II
The purpose of this study was to develop and evaluate topical formulations of Spantide II, a neurokinin-1 receptor (NK-1R) antagonist, for the treatment of inflammatory skin disorders. Spantide II lotion and gel was formulated with and without n-methyl-2-pyrrolidone (NMP) as a penetration enhancer. The release of Spantide II from gels was evaluated using mic
Springer-Verlag.
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5. Effect of a tachykinin antagonist on a nociceptive reflex in the isolated spinal cord-tail preparation of the newborn rat.
1. The pharmacological profile of Spantide, [D-Arg1, D-Trp7,9, Leu11] substance P, as a substance P (SP) antagonist was examined in isolated spinal cords of newborn rats. Potential changes were recorded extracellularly from a lumbar ventral root (L1-L5). Application of SP to the perfusion bath with a brief pressure pulse of 0.05-0.8 s duration produced a dos
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6. Spantide II, an effective tachykinin antagonist having high potency and negligible neurotoxicity.
Spantide (D-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-D-Trp7-Phe8-D-Trp9-++ +Leu10-Leu11-NH2) was introduced as a tachykinin antagonist in 1984 and has served as a starting point in the design of new antagonists that have proven to be more effective and have exhibited no neurological side effects. The most remarkable and unpredictable structural change that significantl
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7. Influence of perivascular peptides on endoneurial blood flow and microvascular resistance in the sciatic nerve of the rat.
1. A variety of vasoactive peptides has been identified in the axon terminals innervating vasa nervorum but their function is unknown. In mesenteric arterioles, substance P (SP) and calcitonin gene-related peptide (CGRP) have been postulated to have a role in tonic vasodilatation. 2. We explored the effect of epineurial capsaicin, SP, CGRP, spantide (SP anta
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8. Effect of vasoactive intestinal peptide, bombesin and substance P on fluid secretion by isolated rat pancreatic ducts.
1. We have used micropuncture techniques to study the regulation of fluid secretion by interlobular ducts isolated from the pancreas of copper-deficient rats. 2. Ducts isolated from different strains of Wistar rats exhibited quantitative differences in basal fluid secretion; however, secretion rates measured in the presence of secretin were similar. 3. Vasoa
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9. Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus
Substance P (SP), a member of the tachykinin family, is widely distributed in the central nervous system and is involved in a variety of physiological processes including cardiovascular function, inflammatory responses, and nociception. We show here that intrahippocampal administration of SP triggers self-sustaining status epilepticus (SSSE) in response to s
The National Academy of Sciences.
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10. Substance P suppresses GABAA receptor function via protein kinase C in primary sensory neurones of bullfrogs.
1. The effects of substance P (SP) and related tachykinins on the function of gamma-aminobutyric acid-A (GABAA) receptors were examined in acutely dissociated neurones of bullfrog dorsal root ganglia (DRG) by using whole-cell voltage-clamp techniques. 2. Application of SP (10 nM to 1 microM) depressed inward currents produced by GABAA receptor activation (IG
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11. Substance P augments tumor necrosis factor release in human monocyte-derived macrophages.
Substance P (SP) is an undecapeptide that has the amino sequence Arg-Pro-Lys-Pro-Gin-Gln-Phe-Phe-Gly-Leu-Met-NH2 and that belongs to a family of structurally related peptides known as tachykinins, the latter are widely distributed in the central nervous system. SP is involved in the biological activities of cells in the immune system, including the induction
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12. Evidence that capsaicin hyperaemia of rat sciatic vasa nervorum is local, opiate-sensitive and involves mast cells.
1. In previous work, we identified a prolonged and intense hyperaemic response of rat sciatic endoneurial vasa nervorum produced by epineurial application of capsaicin. We postulated that this response, which was blocked by substance P (SP) or calcitonin gene-related peptide (CGRP) antagonists, was a result of local release of neuropeptides on the 'feeding'