Somatostatin
Mostrando 13-24 de 543 artigos, teses e dissertações.
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13. Rapid response of hypercortisolism to vandetanib treatment in a patient with advanced medullary thyroid cancer and ectopic Cushing syndrome
Medullary thyroid carcinoma (MTC) may rarely present with paraneoplastic syndromes. Among the most frequent ones are the appearance of diarrhea and ectopic Cushing syndrome (ECS). The ECS in the context of MTC is usually present in patients with distant metastatic disease. The use of drugs such as ketoconazole, metyrapone, somatostatin analogs and etomidate
Arch. Endocrinol. Metab.. Publicado em: 2015-08
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14. Neuropeptides in the posterodorsal medial amygdala modulate central cardiovascular reflex responses in awake male rats
The rat posterodorsal medial amygdala (MePD) links emotionally charged sensory stimuli to social behavior, and is part of the supramedullary control of the cardiovascular system. We studied the effects of microinjections of neuroactive peptides markedly found in the MePD, namely oxytocin (OT, 10 ng and 25 pg; n=6/group), somatostatin (SST, 1 and 0.05 μM; n=
Braz J Med Biol Res. Publicado em: 21/11/2014
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15. Role of high mobility group box-1 and protection of growth hormone and somatostatin in severe acute pancreatitis
In this study, we investigated the potential role of high-mobility group box 1 (HMGB1) in severe acute pancreatitis (SAP) and the effects of growth hormone (G) and somatostatin (S) in SAP rats. The rats were randomly divided into 6 groups of 20 each: sham-operated, SAP, SAP+saline, SAP+G, SAP+S and SAP+G+S. Ileum and pancreas tissues of rats in each group we
Braz J Med Biol Res. Publicado em: 12/09/2014
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16. ANÁLISE DA EXPRESSÃO DOS RECEPTORES DA SOMATOSTATINA (SST1-5) E DA DOPAMINA (DR2) EM ADENOMAS HIPOFISÁRIOS / ANALYSIS OF EXPRESSION OF THE RECEPTORS OF THE SOMATOSTATIN (SST1-5) AND DOPAMINE (DR2) IN PITUITARY ADENOMAS
Pituitary tumors represent 15% of intracranial neoplasms and are usually benign. The treatment primary is surgical resection with exception for prolactinomas because dopamine agonists are very effective in the treatment these tumors. If surgery does not lead to healing, it is necessary other therapeutic strategy in a attempt to control hormone levels and tum
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/03/2012
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17. The influence of selected pathological states on the somatostatin-like immunoreactive (SOM-LI) endocrine cells in the mucosal layer of the porcine descending colon
This study reports on changes in the number of somatostatin-like immunoreactive (SOM-LI) endocrine cells in the porcine descending colon, caused by chemically driven inflammation, axotomy and proliferative enteropathy (PE). The distribution pattern of SOM-LI endocrine cells has been studied using the routine single-labelling immunofluorescence technique. Sem
Pesq. Vet. Bras.. Publicado em: 2012-12
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18. Diagnosis of an ectopic adrenocorticotropic hormonesecreting bronchial carcinoid by somatostatin receptor scintigraphy
Clinics. Publicado em: 2012-08
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19. Diagnostic work-up of gastroenteropancreatic neuroendocrine tumors
Neuroendocrine tumors are a heterogeneous group of malignancies that present a diagnostic challenge. The majority of patients (more than 60%) present with metastatic disease at diagnosis. The diagnosis is based on histopathology, imaging, and circulating biomarkers. The histopathology should contain specific neuroendocrine markers such as chromogranin A, syn
Clinics. Publicado em: 2012
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20. Effect of the administration of octreotide, cabergoline and the association of both on ACTH and cortisol levels in patients with Cushings disease: correlation of clinical response with tumoral expression of the dopamine (DRD2) and somatostatin (SSTR2 and SSTR5) receptors / Efeito da administração de octreotide, cabergolina e a associação de ambos nos níveis de ACTH e cortisol em pacientes com doença de Cushing: correlação da resposta clínica com a expressão tumoral dos receptores de dopamina (DRD2) e de somatostatina (SSTR2 e SSTR5)
Introdução: A doença de Cushing apresenta elevada morbimortalidade. Seu tratamento de escolha é a cirurgia transesfenoidal que possui resultados satisfatórios em cerca de 70% dos casos. Na doença persistente ou recorrente, reabordagem cirúrgica, radioterapia e adrenalectomia bilateral podem ser realizadas, porém, essas opções apresentam como desvan
Publicado em: 2010
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21. Síntese, análise, purificação e biodistribuição em modelo animal do Radiofármaco 177Lu3+-dotatato para uso diagnóstico e terapêutico em tumores neuroendócrinos / SYNTHESIS, ANALYSIS, PURIFICATION AND BIODISTRIBUTION IN AN ANIMAL MODEL OF RADIOPHARMACEUTICAL 177Lu3+- DOTATATO FOR DIAGNOSTIC AND THERAPEUTIC USE IN NEUROENDOCRINE TUMORS
The aim of this work was to propose rationalization in the synthesis, analysis and purification of radiopharmaceutical 177Lu3+-DOTATATO for diagnostic and therapeutic use in neuroendocrine tumors, as well as for evaluating biodistribution of this radiopharmaceutical in an animal-model. The complexation reaction for the synthesis of radiopharmaceutical was ca
Publicado em: 2009
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22. Somatostatin analogs in acromegaly: comparison of clinic response, laboratory and tumor volume with expression of somatostatin receptor subtype in somatotroph tumor / Análogos da somatostatina na acromegalia: comparação da resposta clínica, laboratorial e do volume tumoral com a expressão dos subtipos dos receptores de somatostatina no tumor somatotrófico
Este estudo analisa a expressão dos subtipos de receptores da somatostatina (SSTR) em 39 adenomas secretores de GH. Em 19 pacientes acromegálicos, a resposta clínica, laboratorial e radiológica ao análogo da somatostatina (AS) octreotide-LAR foi comparada à expressão dos SSTR. O SSTR mais freqüentemente expresso foi o SSTR5, seguido pelos SSTR3, SSTR
Publicado em: 2008
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23. PREPARATION OF LYOPHILIZED KIT OF HYNIC-[Tyr3]-OCTREOTATE AND LABELING STUDIES WITH 99m-TECHNETIUM / Preparo do reagente liofilizado HYNIC-[Tyr3]-Octreotato e estudo de marcação com Tecnécio-99m
The development of radiolabeled molecules with high specificity for an organ or tumor has been contributed to the precise diagnostic in nuclear medicine. Somatostatin labeled derivatives constitutes a particular example of labeled peptide applied in the localization of neuroendocrine tumors. Nowadays, the 111In-DTPA-octreotideo is the radiopharmaceutical app
Publicado em: 2008
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24. Expression of somatostatin receptor type 2 (SSTR-2) and its relation with lymphatic metastasis and preoperative clinical features in typical bronchopulmonary carcinoid tumors / Expressão de receptores de somatostatina subtipo 2 (SSTR-2) e a sua relação com metástase linfática e variáveis clínicas pré-operatórias em tumores carcinóides broncopulmonares típicos
Os tumores carcinóides broncopulmonares típicos (CT) são proliferações de células neuroendócrinas. Foram consideradas como adenomas e acreditava-se que não tinham potencial para disseminação hematogênica e linfática. Porém, a ocorrência de metástase linfática e hematogênica acontece em um quinto dos indivíduos acometidos por essa patologia.
Publicado em: 2008