Solid Lipid Nanoparticles
Mostrando 1-12 de 31 artigos, teses e dissertações.
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1. Development and optimization of erythromycin-loaded lipid-based gel by Taguchi design: In vitro characterization and antimicrobial evaluation
The foremost aim of the current research was to prolong and sustain the release of erythromycin (ERY) by preparing a solid lipid nanoparticles (SLNs)-based gel formulation for the safe and effective treatment of acne. ERY-loaded SLNs were developed, and various process variables were optimized with respect to particle size, zeta potential, and entrapment eff
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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2. Preparation and characterization of non-viral gene delivery systems with pEGFP-C1 Plasmid DNA
ABSTRACT In recent years, non-viral delivery systems for plasmid DNA have become particularly important. They can overcome the disadvantages of viral systems such as insertional mutagenesis and unpredicted immunogenicity. Some additional advantages of non-viral gene delivery systems are; good stability, low cost, targetability, delivery of a high amount of g
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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3. Lipid core nanoparticles resembling low-density lipoprotein and regression of atherosclerotic lesions: effects of particle size
Particles are usually polydispersed and size is an important feature for lipid-based drug delivery systems in order to optimize cell-particle interactions as to pharmacologic action and toxicity. Lipid nanoparticles (LDE) with composition similar to that of low-density lipoprotein carrying paclitaxel were shown to markedly reduce atherosclerosis lesions indu
Braz J Med Biol Res. Publicado em: 01/03/2018
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4. Development and Characterization of Vitamin A-Loaded Solid Lipid Nanoparticles for Topical Application
Vitamin A and its esters are commonly found in topical applications because of their advantageous properties, however, have the drawback that are highly sensitive to ultraviolet radiation. The aim of this work was to develop and characterize a novel formulation of solid lipid nanoparticles suitable for topical applications in order to protect vitamin A from
J. Braz. Chem. Soc.. Publicado em: 2017-07
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5. A simple HPLC method for the determination of halcinonide in lipid nanoparticles: development, validation, encapsulation efficiency, and in vitro drug permeation
ABSTRACT Halcinonide is a high-potency topical glucocorticoid used for skin inflammation treatments that presents toxic systemic effects. A simple and quick analytical method to quantify the amount of halcinonide encapsulated into lipid nanoparticles, such as polymeric lipid-core nanoparticles and solid lipid nanoparticles, was developed and validated regard
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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6. Development of a new HPLC method for in vitro and in vivo studies of haloperidol in solid lipid nanoparticles
ABSTRACT A simple and sensitive HPLC method was developed and validated for the quantification of haloperidol in solid lipid nanoparticles (SLNs). The developed method was used for detection of shelf life of haloperidol in SLNs. Calibration curve of haloperidol was also constructed in rat plasma using loratidine as internal standard. In vivo studies were per
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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7. Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies
ABSTRACT Irbesartan is an antihypertensive with limited bioavailability and solid lipid nanoparticles (SLN) is one of the approaches to improve bioavailability. Solid lipid nanoparticles were prepared using glyceryl monostearate by solvent emulsification method followed by probe sonication. Irbesartan loaded SLNs were characterized and optimized by parameter
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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8. SISTEMAS CARREADORES LIPÍDICOS NANOESTRUTURADOS PARA IVERMECTINA E METOPRENO VISANDO CONTROLE DE PARASITAS
The study of characteristics of nanoscale structures and applications now has great interest of researchers from different areas. In this regard, lipid carriers can improve the bioavailability of drugs and the reduction of possible toxicological effects. Thus, the development of nanostructured systems for the agricultural sector, aimed at combating parasites
Quím. Nova. Publicado em: 2016-11
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9. Nanobiotechnology Solutions against Aedes aegypti
United Nations Children's Fund (UNICEF)/United Nations Development Programme (UNDP)/World Bank/World Health Organization (WHO) implemented the Training in Tropical Diseases (TDR) program with excellent results; however, due to current challenges, this active program requires new and innovative solutions. Nowadays, Aedes aegyptis-borne diseases can be added a
J. Braz. Chem. Soc.. Publicado em: 2016-06
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10. Freeze-drying of ampicillin solid lipid nanoparticles using mannitol as cryoprotectant
resumo Nanoparticulas lipídicas sólidas (NLSs) são sistemas coloidais de liberação interessantes, uma vez que reúnem todas as vantagens de nanopartículas lipídicas e poliméricas. A liofilização é um processo amplamente utilizado para melhorar a estabilidade das NLSs e os crioprotetores têm sido usados para diminuir a agregação destas durante e
Braz. J. Pharm. Sci.. Publicado em: 2015-12
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11. Nanoparticles containing curcuminoids (Curcuma longa): development of topical delivery formulation
Solid lipid nanoparticles incorporating Curcuma longa L., Zingiberaceae, curcuminoids were produced by the hot melt emulsion method. A Box–Behnken factorial design was adopted to study the nanoparticles production at different levels of factors such as the percentage of curcuminoids, time of homogenization and surfactant ratio. The optimized nanoparticles
Rev. bras. farmacogn.. Publicado em: 2015-02
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12. Desenvolvimento e caracterização físico-química de nanopartículas lipídicas sólidas para encapsulação de proteínas / Development and physical chemistry characterization of solid lipid nanoparticles for encapsulating proteins
Nanopartículas Lipídicas Sólidas (NLS) vêm sendo investigadas desde o início dos anos 90. As dispersões de NLS apresentam como característica principal a interação com moléculas dos fármacos ou proteínas resultando em uma liberação sustentada e o transporte do princípio ativo até o alvo terapêutico, aumentando assim a sua eficácia de ação
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/08/2012