Solid Dispersion
Mostrando 1-12 de 132 artigos, teses e dissertações.
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1. AVALIAÇÃO DE NANOTUBOS DE CARBONO FUNCIONALIZADOS VISANDO O DESENVOLVIMENTO DE MÉTODOS DE PRÉ-CONCENTRAÇÃO DE ÍONS METÁLICOS E DETERMINAÇÃO POR TÉCNICAS ESPECTROMÉTRICAS E ELETROANALÍTICAS
This review focuses on the use of functionalized carbon nanotubes (CNTs) on the development of preconcentration methods with substantial contributions on selectivity and sensitivity for metal ions determination. CNTs have been usually employed in the development of preconcentration/speciation coupled to spectroanalytical techniques for ions determination at
Quím. Nova. Publicado em: 2020-09
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2. SIMULATION AND EXPERIMENTAL INVESTIGATION OF POWER CONSUMPTION, GAS DISPERSION AND MASS TRANSFER COEFFICIENT IN A MULTI-PHASE STIRRED BIOREACTOR
Abstract Bio-oxidation leaching of refractory gold concentrate was carried out in a typical gas-liquid-solid three-phase stirred bioreactor. The bacteria, which adhered to solid particle surfaces and spread over the liquid phase, require sufficient oxygen and nutrient of carbon and nitrogen, and then the mass transfer rate should be considered. However, the
Braz. J. Chem. Eng.. Publicado em: 13/01/2020
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3. Solid dispersion-based pellet for colon delivery of tacrolimus through time- and pH-dependent layer coating: preparation, in vitro and in vivo studies
The intent of the present investigation is to develop and evaluate colon-specific coated tacrolimus solid dispersion pellet (SDP) that retards drug release in the stomach and small intestine but progressively releases in the colon. Tacrolimus-SDP was prepared by extrusion-spheronization technology and optimized by the micromeritic properties including flowab
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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4. Determination of Plant Growth Regulators in Chinese Herbal Medicine: A Comparison of Liquid (QuEChERS) and Solid (MSPD) Extraction Methods
This work aimed to compare the methods for the determination of twenty plant growth regulators (PGRs) from Chinese herbal medicines by applying liquid and solid extraction methods simultaneously. Quick, easy, cheap, effective, rugged and safe (QuEChERS) and matrix solid-phase dispersion (MSPD) were chosen as the liquid and solid extraction methods, respectiv
J. Braz. Chem. Soc.. Publicado em: 04/07/2019
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5. Preparation and characterization of cefuroxime axetil solid dispersions using poloxamer 188
The main objective of the present work was to enhance the solubility and dissolution rate of poorly water-soluble drug cefuroxime axetil (CA) by formulating it into solid dispersions (SDs) with water soluble carrier poloxamer 188. Different methods were employed to prepare the dispersion, such as: Solvent method (SM), Kneading method (KM), Melt evaporation m
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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6. Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
ABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of th
Matéria (Rio J.). Publicado em: 06/12/2018
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7. Solubility and dissolution enhancement of flurbiprofen by solid dispersion using hydrophilic carriers
ABSTRACT The intent of the current work is to study the effect of polyethylene glycol 8000 and polyethylene glycol 10000 as hydrophilic carriers on dissolution behaviour of flurbiprofen. In the present study, solvent evaporation method was used to prepare flurbiprofen solid dispersions and evaluated for physico-chemical properties, drug-carrier compatibility
Braz. J. Pharm. Sci.. Publicado em: 07/05/2018
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8. Determination of Target Pesticide Residues in Tropical Fruits Employing Matrix Solid-Phase Dispersion (MSPD) Extraction Followed by High Resolution Gas Chromatography
A simple method based on matrix solid-phase dispersion (MSPD) extraction and gas chromatography with electron-capture detection (GC-ECD) is employed to determine pesticide residues in the following tropical fruits: banana, mango, melon, papaya and pineapple. In the MSPD proposed method, C18, silica gel and ethyl acetate presented the best results in the extr
J. Braz. Chem. Soc.. Publicado em: 2018-05
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9. Preparation and physicochemical characterization of meloxicam orally fast disintegration tablet using its solid dispersion
ABSTRACT Meloxicam (MLX) is a non-steroidal, anti-inflammatory drug that is prescribed in the treatment of rheumatoid arthritis and osteoarthritis. MLX is practically insoluble in water and exhibits a slow onset of action. In this study, MLX solid dispersions (MLX SDs) were prepared to improve the water solubility of this poorly water-soluble drug. Then oral
Braz. J. Pharm. Sci.. Publicado em: 05/03/2018
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10. Influence of attrition variables on iron ore flotation
Abstract The presence of slimes is harmful to the flotation process: the performance and consumption of reagents are negatively affected. Traditionally, the desliming stage has been responsible for removing slimes. However, depending on the porosity of the mineral particles, desliming may not be sufficient to maximize the concentration results. An attrition
REM, Int. Eng. J.. Publicado em: 2018-03
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11. The behavior of Aphis gossypii and Aphis craccivora (Hemiptera: Aphididae) and of their predator Cycloneda sanguinea (Coleoptera: Coccinellidae) in cotton-cowpea intercropping systems
ABSTRACT The intercropping is an important cultural practice commonly used in pest management. It is based on the principle that increased plant diversity in the agro-ecosystem can lead to reductions of pest populations in the crop. The current study aimed to assess the impact the colored fiber cotton-cowpea intercropped systems on Aphis gossypii and Aphis c
An. Acad. Bras. Ciênc.. Publicado em: 01/02/2018
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12. Influence of Nanoxides on Diffusivity and Solubility of Hydrogen in Pd-based alloys
The hydrogen interaction in palladium alloys with addition of Ce, Zr and Y was studied. These alloys are produced by arc-melting and then cold rolled into thin foils. Heat treatment at 800ºC for 24h in air atmosphere is applied to induce internal oxidation. Hydrogen permeation tests and TDS (Thermal Desorption Spectroscopy) are carried out to evaluate hydro
Mat. Res.. Publicado em: 11/01/2018