Small Bowel Transplantation
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Remote ischemic preconditioning and tacrolimus in the fetal small bowel transplant in mice
ABSTRACT PURPOSE: To evaluate the effect of remote ischemic preconditioning (IPC-R) in the fetal small bowel transplantation model. METHODS: Two groups were constituted: The Isogenic transplant (ISO, C57BL/6 mice, n=24) and the allogenic transplant (ALO, BALB/c mice, n=24). In each group, the animals were distributed with and without IPC-R. It was obtained
Acta Cir. Bras.. Publicado em: 2016-10
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2. Outcome of pigs with short gut syndrome submitted to orthotopic intestinal transplantation
PURPOSE: To evaluate the current model of small bowel resection and intestinal transplantation in pigs. METHODS: Forty two Large White pigs were distributed in five groups: G1(n=6), G2(n=6) and G3(n=6) were submitted to 80%,100% and 100% plus right colon resection respectively and G4(n=7) and G5(n=5) to 100% SBR plus IT without and with immunosuppression ba
Acta Cir. Bras.. Publicado em: 2015-02
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3. Growth following solid organ transplantation in childhood
One of the ultimate goals of successful solid organ transplantation in pediatric recipients is attaining an optimal final adult height. This manuscript will discuss growth following transplantation in pediatric recipients of kidney, liver, heart, lung or small bowel transplants. Remarkably similar factors impact growth in all of these recipients. Age is a pr
Clinics. Publicado em: 2014-01
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4. Lesão causada pela isquemia seguida de reperfusão em modelo experimental de transplante de intestino em porcos jovens: avaliação por meio de métodos histológicos, imunoistoquímicos e de biologia molecular / Experimental model of intestinal transplantation in pigs: evaluation of the ischemia reperfusion injury by means of histological, and immunohistochemical methods and molecular biology
INTRODUÇÃO: O transplante de intestino (TI) estabeleceu-se como tratamento para pacientes com falência intestinal e complicações da nutrição parenteral. Entretanto, sepse continua sendo a principal causa de mortalidade. A lesão causada pela isquemia seguida de reperfusão (LIR) é apontada como um dos fatores de ruptura da barreira mucosa intestinal,
Publicado em: 2011
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5. Segmental reversal of the small bowel as an alternative to intestinal transplantation in patients with short bowel syndrome.
OBJECTIVE: This article reports the results of segmental reversal of the small bowel on parenteral nutrition dependency in patients with very short bowel syndrome. SUMMARY BACKGROUND DATA: Segmental reversal of the small bowel could be seen as an acceptable alternative to intestinal transplantation in patients with very short bowel syndrome deemed to be depe
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6. Specific acceptance of fetal bowel allograft in mice after combined treatment with anti-intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 antibodies.
OBJECTIVE: The aim of this study was to see whether tolerance could be induced by simultaneous administration of monoclonal antibodies (MoAbs) to intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) after transplantation of fetal small bowel between fully incompatible mice strains. METHODS: Fetal small bowel from eit
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7. Extended myectomy-myotomy. A therapeutic alternative for total intestinal aganglionosis.
OBJECTIVE: That total intestinal aganglionosis (extended Hirschsprung's disease) is uniformly incompatible with life as reported in 1985, is challenged by this series of patients treated over the last 7 years with an alternative therapy, extended myectomy-myotomy of the small bowel. SUMMARY BACKGROUND DATA: A total of 16 neonates worldwide presented with int
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8. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.
Administration of IL-11 prevented lethal graft-versus-host disease (GVHD) in a murine bone marrow transplant (BMT) model (B6 --> B6D2F1) across MHC and minor H antigen barriers (survival at day 50: 90 vs 20%, P < 0.001). Surpisingly, IL-11 administration polarized the donor T cell cytokine responses to host antigen after BMT with a 50% reduction in IFNgamma
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9. Intestinal transplantation in composite visceral grafts or alone.
Under FK 506-based immunosuppression, the entire cadaver small bowel except for a few proximal and distal centimeters was translated to 17 randomly matched patients, of whom two had antigraft cytotoxic antibodies (positive cross-match). Eight patients received the intestine only, eight had intestine in continuity with the liver, and one received a full multi
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10. Antigenaemia during acute graft versus host disease.
AIMS--Animal studies have shown that antigens present within the gut play an important role in the development of acute graft versus host disease (GvHD) following allogeneic bone marrow transplantation (BMT). In previous studies, inert sugars have been found to penetrate the small bowel mucosa after conditioning therapy for BMT; endotoxaemia can also occur d
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11. A new treatment for patients with short-bowel syndrome. Growth hormone, glutamine, and a modified diet.
OBJECTIVE: The purpose of this study was to initially determine if growth hormone or nutrients, given alone or together, could enhance absorption from the remnant small bowel after massive intestinal resection. If clinical improvement were observed, this therapy would then be used to treat patients with the short-bowel syndrome over the long term. SUMMARY BA
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12. The use of jejunal transplants to treat a genetic enzyme deficiency.
INTRODUCTION: The Gunn rat is an excellent animal model of Crigler-Najjar syndrome, type 1. The liver and small intestine synthesize no functional bilirubin uridine diphosphoglucuronosyl transferase and, consequently, the animals cannot conjugate bilirubin. In prior studies, the authors have shown that 15- to 20-cm jejunal transplants from normal Wistar rats