Slco1b3
Mostrando 1-5 de 5 artigos, teses e dissertações.
-
1. Polimorfismos nos genes das proteínas transportadoras de ânions orgânicos na hiperbilirrubinemia neonatal : um estudo de casos e controles
Jaundice usually is a physiological phenomenon among newborns; however, severe hyperbilirubinemia occurs in 5% to 6% of this population. It has been suggested that genetic variation in the genes of bilirubin transporters could enhance the risk of hyperbilirubinemia when co-expressed with other icterogenic conditions. The present study included newborns with
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
-
2. Investigação dos polimorfismos dos genes de polipeptídeos transportadores de ânions orgânicos (OATP) e a resposta ao tratamento com sinvastatina
A prevenção das doenças cardiovasculares é, atualmente, uma das principais metas para o cuidado com a saúde nos países ocidentais. Os inibidores da HMG CoA redutase (estatinas) são os fármacos mais utilizados para a prevenção das doenças cardiovasculares devido a sua eficácia em reduzir os níveis de colesterol e por serem bem tolerados durante o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2009
-
3. Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia
Bilirubin, resulting largely from the turnover of hemoglobin, is found in the plasma in two main forms: unconjugated or conjugated with glucuronic acid. Unconjugated bilirubin is transported into hepatocytes. There, it is glucuronidated by UGT1A1 and secreted into the bile canaliculi. We report a genome wide association scan in 4300 Sardinian individuals for
Oxford University Press.
-
4. Genome-wide association meta-analysis for total serum bilirubin levels
Variation in serum bilirubin is associated with altered cardiovascular disease risk and drug metabolism. We aimed to identify genetic contributors to variability in serum bilirubin levels by combining results from three genome-wide association studies (Framingham heart study, n = 3424; Rotterdam study, n = 3847; Age, Gene, Environment and Susceptibility-Reyk
Oxford University Press.
-
5. Impact of OATP transporters on pharmacokinetics
Membrane transporters are now recognized as important determinants of the transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a family of influx transporters expressed in various tissues important for pharmacokinetics. Of the 11 human OATP transporters, OATP1B1, OATP1B3 and OATP2B1 are expressed on the sinusoidal membrane of h
Blackwell Publishing Ltd.