Skin Penetration
Mostrando 1-12 de 107 artigos, teses e dissertações.
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1. Nanostructured Lipid Carriers Loaded with 17-α-Estradiol Accumulate into Hair Follicles
To improve 17-α-estradiol targeting in alopecia treatment, a formulation of nanostructured lipid carrier (NLC) prepared by the sonication method was developed. The physicochemical characterization showed an average diameter of 96 ± 15 nm and the average zeta potential of -17 ± 6 mV. In addition, the encapsulation efficiency (EE) of 17-α-estradiol, assess
J. Braz. Chem. Soc.. Publicado em: 2020-07
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2. Assessment of an anti-ageing structured cosmetic formulation containing goji berry
Based on previous studies, it has been found that goji berry (GB), popularly known as a ‘miracle fruit’, has excellent antioxidant potential and can be used in the treatment of skin disorders associated with ageing. This study aimed to incorporate GB into a structured cosmetic in order to optimise its penetration. Stability studies of the formulation, de
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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3. PREPARATION AND CHARACTERIZATION OF A QUERCETIN-TETRAETHYL ETHER-BASED PHOTOPROTECTIVE NANOEMULSION
Although Quercetin absorbs in the UVA/UVB electromagnetic region, it is limited for applications as a UV filter due to its low lipophilicity and capacity to penetrate the epidermis. In order to overcome this limitation, we synthetized and evaluated the photo protective properties of a derivative obtained from Quercetin. The derivative was prepared by alkylat
Quím. Nova. Publicado em: 27/05/2019
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4. Postharvest quality of ‘Baigent’ apples as a function of single and multiple preharvest spray aminoetoxivinylglycine and ethephon applications
Resumo O objetivo deste trabalho foi avaliar os efeitos da aplicação pré-colheita de aminoetoxivinilglicina (AVG), em dose única ou parcelada, combinado ou não com etefom, em macieiras ‘Baigent’, e da data de colheita, sobre a qualidade dos frutos após o armazenamento. O experimento foi conduzido em pomar comercial, no município de Vacaria/RS, na
Rev. Bras. Frutic.. Publicado em: 20/05/2019
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5. Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations
The present study was aimed at preparation of transdermal patches of tizanidine HCl, evaluation of the effect of polymers on in vitro release pattern of the drug, and the effect of permeation enhancers on the penetration of the drug through the rabbit skin. Various proportions of hydrophilic (HPMC) and hydrophobic (Eudragit L-100) polymers were used with PEG
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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6. Physical methods for topical skin drug delivery: concepts and applications
Topical drug delivery is an interesting approach to treat skin diseases and to avoid pain and low patient compliance in cases where a systemic delivery is required. However, the stratum corneum, which is the outermost skin layer, strongly protects the body from the entrance of substances, especially those hydrophilic. In this context, different physical meth
Braz. J. Pharm. Sci.. Publicado em: 08/11/2018
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7. Skin manifestations of tick bites in humans
Abstract: Ticks are blood-sucking arthropods that attach to human skin through oral devices causing diverse initial cutaneous manifestations, and may also transmit serious infectious diseases. In certain situations, the Health Teams (and especially dermatologists) may face difficulties in identifying the lesions and associating them to the parasites. To assi
An. Bras. Dermatol.. Publicado em: 2018-03
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8. Natural membranes of Hevea brasiliensis latex as delivery system for Casearia sylvestris leaf components
ABSTRACT Natural latex from Hevea brasiliensis (Wild. ex A.Juss) Müll.Arg., Euphorbiaceae, showed angiogenic action and Casearia sylvestris Sw., Salicaceae, leaf derivatives presented anti-inflammatory and wound healing activities. Therefore, an association of these effects was interesting for wound healing applications. The aims of this study were the deve
Rev. bras. farmacogn.. Publicado em: 2018-01
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9. Promotion of cutaneous penetration of nifedipine for nanoemulsion
ABSTRACT This article reports the development and characterization of a nanoemulsion (NE) able to improve the cutaneous penetration of nifedipine. NE with nifedipine was development and characterized, presenting droplet size of 20 nm with low polydispersity index (IP<0.1), spherical shape without aggregation, pH compatible with typical skin levels and stabil
Braz. J. Pharm. Sci.. Publicado em: 06/07/2017
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10. In vitro evaluation of cutaneous penetration of acyclovir from semisolid commercial formulations and relation with its effective antiviral concentration
ABSTRACT The evaluation of drug permeation/penetration of semisolid formulations into animal skin can be useful to supplement the pharmaceutical equivalence. This paper describes the in vitro assessment of acyclovir (ACV) into porcine skin from commercial formulations with etermination of drug concentration in different layers of cutaneous tissue to correlat
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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11. Evaluation of skin absorption of drugs from topical and transdermal formulations
ABSTRACT The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal f
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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12. Synergic effects between ocellatin-F1 and bufotenine on the inhibition of BHK-21 cellular infection by the rabies virus
Abstract Background Rabies is an incurable neglected zoonosis with worldwide distribution characterized as a lethal progressive acute encephalitis caused by a lyssavirus. Animal venoms and secretions have long been studied as new bioactive molecular sources, presenting a wide spectrum of biological effects, including new antiviral agents. Bufotenine, for i
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 31/12/2015