Simvastatin
Mostrando 25-36 de 135 artigos, teses e dissertações.
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25. Entendendo o processo químico de bioativação da sinvastatina por métodos experimentais e computacionais: uma aula prática
Cholesterol is a lipid which in high concentration can be an important risk factor for coronary diseases and atherosclerotic lesions. This lipid presents an endogenous biosynthesis that involves several steps; one of them is modulated by the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase). HMG-CoA reductase is inhibited by statins,
Quím. Nova. Publicado em: 2016-05
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26. Hypolipidemic and antiatherogenic effects of Cynara scolymus in cholesterol-fed rats
ABSTRACT Cynara scolymus L., Asteraceae, are traditionally used to treat dyspepsia. This study evaluated the hypolipidemic and antiatherogenic effects of an aqueous extract prepared from the leaves of C. scolymus in rat's model. Hypercholesterolemic rats (1% cholesterol and 0.5% cholic acid for 15 days) were treated (0.5 ml/200 g) with extract of C. scolymus
Rev. bras. farmacogn.. Publicado em: 2016-04
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27. Antioxidant effect of simvastatin throught oxidative imbalance caused by lisdexamfetamine dimesylate
O presente estudo tem o objetivo de investigar diretamente os efeitos comportamentais e antioxidantes da sinvastatina em um modelo de mania bipolar induzida por dimesilato de lisdexanfetamina. Ratos Wistar foram tratados durante 30 dias com simvastatina. No 24º dia após o início do tratamento, foi administrada dimesilato de lisdexanfetamina durante 7 dias
An. Acad. Bras. Ciênc.. Publicado em: 05/02/2016
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28. Simvastatin inhibits planktonic cells and biofilms ofCandida and Cryptococcusspecies
ABSTRACTThe antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested againstCandida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug
Braz J Infect Dis. Publicado em: 2015-10
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29. CYP3A5 genotyping for assessing the efficacy of treatment with simvastatin and atorvastatin
In this work, we examined the impact of polymorphism in the cytochrome P450 (CYP) 3A5 gene, CYP3A5*1 (6986A > G, rs 776746), on the reduction in the lipid levels caused by simvastatin and atorvastatin. We studied 350 hyperlipidemic patients who received 10-40 mg of atorvastatin (n = 175) or simvastatin (n = 175) daily. Genotyping for CYP3A5 was done by PCR-R
Genet. Mol. Biol.. Publicado em: 2015-06
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30. Heart and systemic effects of statin pretreatment in a rat model of abdominal sepsis. Assessment by Tc99m-sestamibi biodistribition
PURPOSE:To evaluate the heart and the Tc-99m-sestamibi biodistribution after statin pretreatment in a rat model of abdominal sepsis.METHODS:Twenty-four Wistar rats were randomly distributed into four groups (n=6 per group): 1) sepsis with simvastatin treatment, 2) sepsis with vehicle, 3) sham control with simvastatin and 4) sham control with vehicle. 24 hour
Acta Cir. Bras.. Publicado em: 2015-06
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31. Investigation of the Environmental Transport of Human Pharmaceuticals to Surface Water: A Case Study of Persistence of Pharmaceuticals in Effluent of Sewage Treatment Plants and Hospitals in Malaysia
The present work reports the occurrence and monitoring of 11 pharmaceuticals (i.e., caffeine, prazosin, enalapril, carbamazepine, nifedipine, gliclazide, levonorgestrel, simvastatin, hydrochlorothiazide, diclofenac-Na and mefenamic acid) in surface water and in the influent and effluent of sewage treatment plants (STPs) and hospitals (HSPs). A total of 105 w
J. Braz. Chem. Soc.. Publicado em: 2015-06
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32. The effect of simvastatin on relapse of tooth movement and bone mineral density in rats measured by a new method using microtomography
PURPOSE: To evaluate the effect of simvastatin on relapse of tooth movement in rats using microtomography (micro CT), as well as the correlation of bone density with the orthodontic relapse.METHODS: Twenty-five adult male Wistar rats, divided into two groups, had stainless steel springs installed on left maxillary first molar. The molars were moved for 18 da
Acta Cir. Bras.. Publicado em: 2015-05
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33. Quick and simple LC-MS/MS method for the determination of simvastatin in human plasma: application to pharmacokinetics and bioequivalence studies
Desenvolveu-e e validou-se um método simples, rápido e sensível baseado na cromatografia líquida acoplada à espectrometria de massas em tandempara a quantificação de sinvastatina em plasma humano. Após um simples preparo de amostras utilizando extração com éter metil-terc-butílico, o analito e seu padrão interno (lovastatina) foram analisados po
Braz. J. Pharm. Sci.. Publicado em: 2014-09
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34. Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy
It is not known whether the addition of ezetimibe to statins adds cardiovascular protection beyond the expected changes in lipid levels. Subjects with coronary heart disease were treated with four consecutive 1-week courses of therapy (T) and evaluations. The courses were: T1, 100 mg aspirin alone; T2, 100 mg aspirin and 40 mg simvastatin/10 mg ezetimibe; T3
Braz J Med Biol Res. Publicado em: 15/04/2014
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35. Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats
PURPOSE: To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae.METHODS: Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ce
Acta Cir. Bras.. Publicado em: 2014-03
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36. The effect of simvastatin on the regeneration of surgical cavities in the femurs of rabbits
PURPOSE:To evaluate the effect of a local application of simvastatin gel in repairing bone defects in the femurs of rabbits.METHODS:Two standard surgical cavities were created in the femoral epiphysis of 18 rabbits. In the simvastatin group (SG), the cavities were filled with a collagen sponge soaked in 0.5 ml of a simvastatin (1 mg) gel, and the cavities we
Acta Cir. Bras.. Publicado em: 2014-02