Signaling
Mostrando 25-36 de 10900 artigos, teses e dissertações.
-
25. Signaling Honesty: Institutional Strength and Voters’ Concern About Corruption in a Model of Electoral Competition
Resumo Quando os eleitores se preocupam com a honestidade de seus líderes políticos, políticos office seekers — sejam corruptos ou não — têm fortes incentivos para se comportar como se fossem realmente honestos. Construímos um jogo simples de sinalização no qual o político no poder desconhece a parcela do eleitorado que se preocupa com a corrup�
Rev. Bras. Econ.. Publicado em: 2020-09
-
26. Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells
Macrophages play pivotal roles in host defense and immune homeostasis, which have two major functional polarization states, the classically activated M1 and the alternatively activated M2. Interleukin (IL)-17A is an immune modulator able to shape macrophage phenotypes. Wnt/β-catenin is a developmental signaling pathway that plays crucial roles in morphogene
Braz J Med Biol Res. Publicado em: 2020-08
-
27. Cardiovascular involvement in COVID-19: not to be missed
Abstract In December 2019, a striking appearance of new cases of viral pneumonia in Wuhan led to the detection of a novel coronavirus (SARS-CoV2). By analyzing patients with severe manifestations, it became apparent that 20 to 35% of patients who died had preexisting cardiovascular disease. This finding warrants the important need to discuss the influence of
Braz. J. Cardiovasc. Surg.. Publicado em: 2020-08
-
28. Corticotropin-releasing factor receptor signaling and modulation: implications for stress response and resilience
Abstract Introduction In addition to their role in regulation of the hypothalamic-pituitary-adrenal-axis, corticotropin-releasing factor (CRF) and its related peptides, the urocortins, are important mediators of physiological and pathophysiological processes of the central nervous, cardiovascular, gastrointestinal, immune, endocrine, reproductive, and skin
Trends Psychiatry Psychother.. Publicado em: 2020-06
-
29. Establishment of a simple and efficient platform for car-t cell generation and expansion: from lentiviral production to in vivo studies
ABSTRACT Introduction: Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19 + B-cell malignancies in numerous clinical trials. The CAR molecule, which recognizes cell-surface tumor-associated antigen independently of human leukocyte antigen (HLA), is composed by
Hematol., Transfus. Cell Ther.. Publicado em: 2020-06
-
30. Growth Hormone insensitivity (Laron syndrome): Report of a new family and review of Brazilian patients
Abstract Laron’s syndrome (LS) is a rare genetic disorder characterized by insensitivity to growth hormone (GH). Up to the present time, over 70 mutations of GH receptor (GHR) gene have been identified leading to GH/insulin-like growth factor type 1 (IGF1) signaling pathway defect. The number of LS patients worldwide is unknown, as many are probably undiag
Genet. Mol. Biol.. Publicado em: 20/01/2020
-
31. Effects of growth hormone in the central nervous system
ABSTRACT Growth hormone (GH) is best known for its effect stimulating tissue and somatic growth through the regulation of cell division, regeneration and proliferation. However, GH-responsive neurons are spread over the entire central nervous system, suggesting that they have important roles in the brain. The objective of the present review is to summarize a
Arch. Endocrinol. Metab.. Publicado em: 10/01/2020
-
32. Insulin signaling in the whole spectrum of GH deficiency
ABSTRACT GH is one of the insulin counterregulatory hormones which acts in the opposite way to insulin, increasing the glucose production by the liver and kidneys and decreasing glucose uptake from peripheral tissues, thus being a hyperglycemic hormone. When in excess, as in acromegaly, it induces glucose intolerance and diabetes. As expected, patients with
Arch. Endocrinol. Metab.. Publicado em: 10/01/2020
-
33. Total Panax notoginseng saponin inhibits balloon injury-induced neointimal hyperplasia in rat carotid artery models by suppressing pERK/p38 MAPK pathways
Total Panax notoginseng saponin (TPNS) is the main bioactivity compound derived from the roots and rhizomes of Panax notoginseng (Burk.) F.H. Chen. The aim of this study was to investigate the effectiveness of TPNS in treating vascular neointimal hyperplasia in rats and its mechanisms. Male Sprague-Dawley rats were randomly divided into five groups, sham (co
Braz J Med Biol Res. Publicado em: 2020-01
-
34. Co-transfection of hepatocyte growth factor and truncated TGF-β type II receptor inhibit scar formation
Wound scarring remains a major challenge for plastic surgeons. Transforming growth factor (TGF)-β plays a key role in the process of scar formation. Previous studies have demonstrated that truncated TGF-β type II receptor (t-TGF-βRII) is unable to continue signal transduction but is still capable of binding to TGF-β, thereby blocking the TGF-β signaling
Braz J Med Biol Res. Publicado em: 2020-01
-
35. Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway
Abstract Purpose: Myocardial ischemia/reperfusion (Ml/R) injury is a leading cause of damage in cardiac tissues, with high rates of mortality and disability. Biochanin A (BCA) is a main constituent of Trifolium pratense L. This study was intended to explore the effect of BCA on Ml/R injury and explore the potential mechanism. Methods: In vivo MI/R injury w
Acta Cir. Bras.. Publicado em: 20/12/2019
-
36. BMP4 Induces Cardiomyocyte Hypertrophy Through the Activation of ERK 1/2 Signaling Pathway in H9c2 Cells
Abstract Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic protein family which plays an important role in bone formation, inflammation and cardiac hypertrophy. The aim of this study was to investigate the underlying molecular mechanism that BMP4-induced cardiomyocyte hypertrophy. H9c2 cells were used to measure cell surface area and
Braz. arch. biol. technol.. Publicado em: 20/12/2019