Sickle Cell
Mostrando 13-24 de 662 artigos, teses e dissertações.
-
13. Association between inflammatory molecules, nitric oxide metabolites and leg ulcers in individuals with sickle cell anemia
Abstract Introduction Leg ulcers (LUs) are relatively common in patients with sickle cell anemia (SCA). The role of inflammation and nitric oxide (NO) pathways in the pathophysiology of the LU is not understood. Objective The aim of this study was to verify the association between inflammatory molecules and nitric oxide metabolites (NOx) and the occurrence
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
-
14. Follow-up of children with sickle cell anemia screened with transcranial Doppler and enrolled in a primary prevention program of ischemic stroke
ABSTRACT Background: Stroke is a serious complication of sickle cell anemia (SCA). The transcranial Doppler (TCD) is the risk-screening tool for ischemic strokes. The objective of the study was to describe the clinical progression of children with SCA who presented with high risk for stroke by TCD or relevant changes by magnetic resonance angiography (MRA)
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
-
15. Main Complications during Pregnancy and Recommendations for Adequate Antenatal Care in Sickle Cell Disease: A Literature Review
Resumo Doença falciforme (DF) é a condição genética mais comum no mundo, com uma prevalência variável nos continentes. A substituição de um nucleotídeo muda um aminoácido na cadeia da β globina, e altera a estrutura normal da hemoglobina, que é então chamada de hemoglobina S, e pode ser herdada em homozigose (HbSS) ou heterozigose (HbSC, HbSβ)
Revista Brasileira de Ginecologia e Obstetrícia. Publicado em: 2022
-
16. Prevalence of clinical manifestations suggestive of depression in patients with sickle cell disease: a review
RESUMO Objetivo: Avaliar a prevalência mundial de manifestações clínicas sugestivas de depressão em portadores de doença falciforme. Métodos: Realizou-se uma busca sistemática nas bases de dados eletrônicas PubMed®, LILACS e SciELO, para identificação dos estudos transversais, publicados em inglês ou português nos últimos 10 anos, que avalia
Jornal Brasileiro de Psiquiatria. Publicado em: 2022
-
17. Hemoglobin S identification in blood donors: A cross section of prevalence
ABSTRACT Introduction: In Brazil, the sickle cell trait (SCT) has an average prevalence of 4% in the general population and 6-10% among Afro-descendants. Although SCT is highly prevalent, a large segment of the population ignores their status. The Therapeutic Guidelines prohibit the transfusion of SCT red blood cells into patients with hemoglobin disorders
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
-
18. Generation of hematopoietic stem/progenitor cells with sickle cell mutation from induced pluripotent stem cell in serum-free system
ABSTRACT Introduction Sickle cell disease (SCD) is a monogenic disease and it is estimated that 300,000 infants are born annually with it. Most treatments available are only palliative, whereas the allogeneic hematopoietic stem cell transplantation offers the only potential cure for SCD. Objective Generation of human autologous cells, when coupled with ind
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
-
19. Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients
ABSTRACT Introduction Mutations affecting genes involved in oxidative and signaling pathways may be associated with kidney disease in sickle cell anemia. We determined the allele and genotype frequencies of some polymorphisms in the promoter regions of the Heme Oxygenase-1 (HMOX1) [rs2071746 (A > T) and (GT)n repeats, short (S) and long (L) alleles] and Bon
Hematol., Transfus. Cell Ther.. Publicado em: 2021-06
-
20. Acute chest syndrome and COVID-19 in sickle cell disease pediatric patients
ABSTRACT Autoimmune diseases are an important field for the development of bone marrow transplantation, or hematopoietic stem cell transplantation. In Europe alone, almost 3000 procedures have been registered so far. The Brazilian Society for Bone Marrow Transplantation (Sociedade Brasileira de Transplantes de Medula Óssea) organized consensus meetings for
Hematol., Transfus. Cell Ther.. Publicado em: 2021-03
-
21. Hemoglobinopathy and pediatrics in the time of COVID-19
ABSTRACT Introduction: It is important to know if patients with hemoglobinopathy could be more susceptible to COVID-19. Objective: Analyze SARS-CoV-2 infection in pediatric patients with hemoglobinopathy. Methods: Using the online platforms LILACS, PUBMED and EMBASE, on 17- JUL-2020 a search was made for the terms COVID-19 and SARS-CoV-2 associated with "
Hematol., Transfus. Cell Ther.. Publicado em: 2021-03
-
22. Predictors associated with sickle cell nephropathy: a systematic review
SUMMARY INTRODUCTION: Sickle cell anemia affects more than 30 million people worldwide. Chronic kidney disease develops in 40% of individuals. The death rate of patients with sickle nephropathy is still high, with little known predictors related to its development. To answer the question “What predictors are associated with the onset of chronic kidney dis
Rev. Assoc. Med. Bras.. Publicado em: 2021-02
-
23. Erythema annulare centrifugum associated with chronic amitriptyline intake,
ABSTRACT Introduction: It is important to know if patients with hemoglobinopathy could be more susceptible to COVID-19. Objective: Analyze SARS-CoV-2 infection in pediatric patients with hemoglobinopathy. Methods: Using the online platforms LILACS, PUBMED and EMBASE, on 17- JUL-2020 a search was made for the terms COVID-19 and SARS-CoV-2 associated with "
An. Bras. Dermatol.. Publicado em: 2021-02
-
24. Factors Predicting Heart Failure in Children Admitted to a Pediatric Emergency Ward in a Developing Country
Abstract Background Heart failure is an important cause of morbidity and mortality in children. Objective To determine the clinical characteristics of children with acute heart failure syndrome in the emergency ward of River state university teaching hospital, Nigeria and identify factors associated with poor outcomes. Methods This was an 18month retro
Int. J. Cardiovasc. Sci.. Publicado em: 2020-12