Sh Sy5y Cells
Mostrando 1-12 de 45 artigos, teses e dissertações.
-
1. Antitumoral effects of Amblyomma sculptum Berlese saliva in neuroblastoma cell lines involve cytoskeletal deconstruction and cell cycle arrest
Resumo As propriedades antitumorais de extratos de glândulas salivares de carrapatos ou proteínas recombinantes foram relatadas recentemente, mas pouco se sabe sobre as propriedades antitumorais dos componentes secretados da saliva. O objetivo deste estudo foi investigar o efeito in vitro da saliva bruta do carrapato duro Amblyomma sculptum sobre as linha
Rev. Bras. Parasitol. Vet.. Publicado em: 14/02/2019
-
2. Cytotoxicity of hydroxydihydrobovolide and its pharmacokinetic studies in Portulaca oleracea L. extract
ABSTRACT Hydroxydihydrobovolide (HDB) was for the first time isolated from Portulaca oleracea L. and then its cytotoxicity against SH-SYTY cells was studied. Moreover, a rapid and sensitive ultra-high performance liquid chromatographic (UHPLC) method with bergapten as internal standard (IS) was developed and validated to investigate the pharmacokinetics of H
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
-
3. Ropinirole alters gene expression profiles in SH-SY5Y cells: a whole genome microarray study
Ropinirole (ROP) is a dopamine agonist that has been used as therapy for Parkinson's disease. In the present study, we aimed to detect whether gene expression was modulated by ROP in SH-SY5Y cells. SH-SY5Y cell lines were treated with 10 µM ROP for 2 h, after which total RNA was extracted for whole genome analysis. Gene expression profiling revealed that 11
Braz J Med Biol Res. Publicado em: 19/01/2016
-
4. Downregulation of survivin by siRNA inhibits invasion and promotes apoptosis in neuroblastoma SH-SY5Y cells
Neuroblastoma is a solid tumor that occurs mainly in children. Malignant neuroblastomas have a poor prognosis because conventional chemotherapeutic agents are not very effective. Survivin, a member of the inhibitor of the apoptosis protein family, plays a significant role in cell division, inhibition of apoptosis, and promotion of cell proliferation and inva
Braz J Med Biol Res. Publicado em: 23/05/2014
-
5. Neuropatia diabética : estudo dos mecanismos moleculares envolvidos com a neurotoxicidade do metilglioxal e do glicolaldeído em células diferenciadas de neuroblastoma humano SH-SY5Y
Neuropatia é a complicação mais comum e mais debilitante da Diabetes Mellitus, a longo prazo presente em mais de 50% dos pacientes que possuem a doença. A hiperglicemia induz estresse oxidativo nos neurônios de diabéticos acarretando a ativação de múltiplas vias bioquímicas, as quais são potenciais alvos terapêuticos para a neuropatia diabética.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
-
6. Efeitos da alfa-sinucleína na modulação da atividade do fator de transcrição nuclear kB em células SH-SY5Y. / Activation of trasnscription fator kB induced by alpha-synuclein in SH-SY5Y cells.
Parkinsons Disease (PD) is a neurodegenerative disease. The characteristics and symptoms are well defined; nevertheless its etiology remains unknown. The sporadic PD is characterized by the presence of Lewy Body (aggregate of proteins) inside the neurons. Alpha-synuclein is a soluble protein present in the pre synaptic terminal of neurons. Evidences suggest
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2011
-
7. Lineage-specific regulation of the vasoactive intestinal peptide gene in neuroblastoma cells is conferred by 5.2 kilobases of 5'-flanking sequence.
The expression of a transfected plasmid containing 5.2 kilobases (kb) of 5' regulatory DNA sequence of the human vasoactive intestinal peptide (VIP) gene attached to coding sequences of the reporter gene chloramphenicol acetyltransferase (CAT) was compared with endogenous VIP expression in subclones of the human neuroblastoma cell line SK-N-SH. These subclon
-
8. Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate
Sequential steps in the activation of the pro-apoptotic protein Bax are described for cells with different sensitivity to cytotoxins. SH-EP1 and SH-SY5Y human neuroblastoma cells, derived from a single precursor cell line, differed in their sensitivity to taxol but showed the same sensitivity to cisplatin. Both drugs, in both cell lines, induced exposure of
Oxford University Press.
-
9. Insulin-like growth factor I shifts from promoting cell division to potentiating maturation during neuronal differentiation.
SH-SY5Y neuroblastoma cells undergo neuronal differentiation and their proliferation is inhibited when they are treated with phorbol 12-myristate 13-acetate (PMA). Insulin and insulin-like growth factor I (IGF-I) are mitogens for the nontreated SH-SY5Y cells, whereas the proliferative response to such factor stimulation is lost upon differentiation, in spite
-
10. Endogenous formation of morphine in human cells
Morphine is a plant (opium poppy)-derived alkaloid and one of the strongest known analgesic compounds. Studies from several laboratories have suggested that animal and human tissue or fluids contain trace amounts of morphine. Its origin in mammals has been believed to be of dietary origin. Here, we address the question of whether morphine is of endogenous or
National Academy of Sciences.
-
11. Decreased intracellular calcium mediates the histamine H3-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings
Activation of presynatic histamine H3 receptors (H3R) down-regulates norepinephrine exocytosis from cardiac sympathetic nerve terminals, in both normal and ischemic conditions. Analogous to the effects of α2-adrenoceptors, which also act prejunctionally to inhibit norepinephrine release, H3R-mediated antiexocytotic effects could result from a decrease
The National Academy of Sciences.
-
12. Differences in replication of attenuated and neurovirulent polioviruses in human neuroblastoma cell line SH-SY5Y.
A base change from C to U at position 472 of the 5' noncoding region of the poliovirus genome is known to be a major determinant of attenuation in the P3/Sabin vaccine strain. To determine the biochemical basis for the attenuated phenotype imparted by this mutation, a cell line in which replication of neurovirulent and attenuated viruses could be distinguish