Serineproteases
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Avaliação das atividades farmacológicas de uma serinoprotease, isolada a partir do veneno total de Brothrops barnetti / Evaluation of pharmacological activities of a serine protease, isolated from the venom total Brothrops barnetti
Os venenos de serpentes contêm uma variedade de proteínas que são estudadas no mundo pela importância biológica e farmacológica. Dentro de sua complexa composição, o veneno apresenta enzimas proteases, como as metaloproteases e serinoproteases que estão envolvidas em distúrbios hemostáticos e coagulantes, interferindo na agregação plaquetária.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/03/2012
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2. Neutralization of pharmacological and toxic activities of Bothrops jararacussu snake venom and isolated myotoxins by Serjania erecta methanolic extract and its fractions
Most of the snakebites recorded in Brazil are caused by the Bothrops genus. Given that the local tissue damage caused by this genus cannot be treated by antivenom therapy, numerous studies are focusing on supplementary alternatives, such as the use of medicinal plants. Serjania erecta has already demonstrated anti-inflammatory, antiseptic and healing propert
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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3. Classificação estrutural de famílias de proteínas com base em mas de contatos.
The objective of this work was to verify if it is possible to classify protein chain structures using only the chemical interactions between its residues. Through contact maps and using three different metrics based on image processing techniques we have showed that we are able to classify such structures in families of similar structure and function with pr
Publicado em: 2008
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4. Effect of serine-proteases inhibitor, berenil, on the feeding efficiency, proteolytic activity and post- embryonic development of Anticarsia gemmatalis (Lepidoptera: Noctuidae) / Efeito do inibidor de serino-proteases, berenil, sobre a eficiência alimentar, atividade proteolítica e desenvolvimento pós-embrionário de Anticarsia gemmatalis (Lepidoptera: Noctuidae)
Inibidores de proteases podem reduzir a eficiência digestiva, retardar o desenvolvimento e diminuir a atividade proteolítica do inseto, resultando em aumento da mortalidade pela deficiência de aminoácidos livres para a manutenção das funções vitais. Este trabalho teve por objetivos avaliar se concentrações crescentes do inibidor sintético de serin
Publicado em: 2007
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5. Purification and investigation of the physical-chemical protease inhibitors properties from acacia plumosa lowe seeds. / Purificação e investigação de propriedades físico-químicas de inibidores de proteases extraídos das sementes de aácia plumosa Lowe.
Seeds of plants belonging to Leguminosae family are rich sources of protease inhibitors. The Acacia genus is one of the most important members of this group. In this work, novel protease inhibitors from Acacia plumose Lowe seeds have been described. From the saline extract of mature seeds, the inhibitors were purified by size exclusion chromatography on Supe
Publicado em: 2006
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6. Thermodynamic evaluation and modeling of proton and water exchange associated with benzamidine and berenil binding to ß-trypsin
Serine-proteases are involved in vital processes in virtually all species. They are important targets for researchers studying the relationships between protein structure and activity, for the rational design of new pharmaceuticals. Trypsin was used as a model to assess a possible differential contribution of hydration water to the binding of two synthetic i
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-11
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7. Mouse Aortic Ring Assay: A New Approach of the Molecular Genetics of Angiogenesis
Angiogenesis, a key step in many physiological and pathological processes, involves proteolysis of the extracellular matrix. To study the role of two enzymatic families, serine-proteases and matrix metalloproteases in angiogenesis, we have adapted to the mouse, the aortic ring assay initially developed in the rat. The use of deficient mice allowed us to demo
Biological Procedures Online.