Sequencing Problem
Mostrando 1-12 de 113 artigos, teses e dissertações.
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1. [PROVISIONAL] Resistance mutations of NS3 and NS5b in treatment-naïve patients infected with Hepatitis C virus in Santa Catarina and Rio Grande do Sul States, Brazil
Abstract Hepatitis C virus (HCV) infection is a worldwide health problem. Nowadays, direct-acting antiviral agents (DAAs) are the main treatment; however, the high level of variability of HCV lead to development of resistance-associated variants (RAVs). Thus, look into the RAVs among infected patients is an important tool for monitoring the efficacy of the t
Genet. Mol. Biol.. Publicado em: 21/10/2019
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2. Direct sequencing of blocks in stochastic models with multi-mines and multi-destinations
Abstract Mining Scheduling is the one that maximizes profit from mining over time. By means of computational methods, the deposit is discretized in blocks and algorithms are used to consummate this objective. The methods that are widely known nowadays for mining scheduling optimization of a discrete block model were based on graph theory, and among those mos
REM, Int. Eng. J.. Publicado em: 16/09/2019
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3. Phylogenetic analysis and genotype distribution of Hepatitis B Virus (HBV) in Roraima, Brazil
ABSTRACT Hepatitis B virus (HBV) infection is a serious global health problem. HBV has a high viral genetic diversity, with 10 genotypes recognized. In Brazil, the Roraima State is the third in the Northern region regarding the number of hepatitis B cases. On the other hand, few data on HBV genotyping and phylogenetic analysis are available. The purpose of t
Rev. Inst. Med. trop. S. Paulo. Publicado em: 19/07/2018
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4. Report of East-Central South African Chikungunya virus genotype during the 2016 outbreak in the Alagoas State, Brazil
ABSTRACT Chikungunya virus (CHIKV) causes a self-limiting disease characterized by the onset of fever, skin rash and persistent arthralgia. In the last decade, it has emerged as a serious public health problem causing several outbreaks around the world. Here, we report the CHIKV genotype characterization during the 2016 CHIKV outbreak in Alagoas State, Brazi
Rev. Inst. Med. trop. S. Paulo. Publicado em: 23/04/2018
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5. Radiotherapy modulates expression of EGFR, ERCC1 and p53 in cervical cancer
Cervical cancer is a public health problem and the molecular mechanisms underlying radioresistance are still poorly understood. Here, we evaluated the modulation of key molecules involved in cell proliferation, cell cycle and DNA repair in cervical cancer cell lines (CASKI and C33A) and in malignant tissues biopsied from 10 patients before and after radiothe
Braz J Med Biol Res. Publicado em: 13/11/2017
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6. Evaluation of resistance acquisition during tuberculosis treatment using whole genome sequencing
Abstract Tuberculosis (TB) is still considered a major global public health problem in the world and there is a concern about the worldwide increase of drug-resistance (DR). This paper describes the analysis of three Mycobacterium tuberculosis isolates from a single patient collected over a long treatment period of time. DR was initially investigated through
Braz J Infect Dis. Publicado em: 2016-06
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7. Molecular characterization of microbial contaminants isolated from Umbilical Cord Blood Units for transplant
ABSTRACT Disposal of Umbilical Cord Blood Units due to microbial contamination is a major problem in Cord Blood Banks worldwide as it reduces the number of units available for transplantation. Additionally, economic losses are generated as result of resources and infrastructure used to obtain such units. Umbilical Cord Blood Units that showed initial microbi
Braz J Infect Dis. Publicado em: 2015-12
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8. GRAPH PROPERTIES OF MINIMIZATION OF OPEN STACKS PROBLEMS AND A NEW INTEGER PROGRAMMING MODEL
The Minimization of Open Stacks Problem (MOSP) is a Pattern Sequencing Problem that often arises in industry. Besides the MOSP, there are also other related Pattern Sequencing Problems of similar relevance. In this paper, we show that each feasible solution to the MOSP results from an ordering of the vertices of a graph that defines the instance to solve, an
Pesqui. Oper.. Publicado em: 2015-08
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9. BIOHYDROGEN FROM CHEESE WHEY TREATMENT IN AN AnSBBR: ACHIEVING PROCESS STABILITY
AbstractAn AnSBBR (anaerobic sequencing batch reactor containing biomass immobilized on an inert support) with liquid phase recirculation, containing a 3.5 L working volume, treated 1.5 L of cheese whey wastewater in 3 and 4 h cycles at 30 ºC to produce biohydrogen. From startup the bioreactor presented process instability. To overcome this problem the foll
Braz. J. Chem. Eng.. Publicado em: 2015-06
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10. Detection of bla KPC-2 in Proteus mirabilis in Brazil
INTRODUCTION : Infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing isolates pose a major worldwide public health problem today. METHODS : A carbapenem-resistant Proteus mirabilis clinical isolate was investigated for plasmid profiles and the occurrence of β-lactamase genes. RESULTS : The isolate exhibited resistance to ertapenem and im
Rev. Soc. Bras. Med. Trop.. Publicado em: 2015-01
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11. HIGH SENSITIVE PCR METHOD FOR DETECTION OF PATHOGENIC Leptospira spp. IN PARAFFIN-EMBEDDED TISSUES
This study describes the development and application of a new PCR assay for the specific detection of pathogenic leptospires and its comparison with a previously reported PCR protocol. New primers were designed for PCR optimization and evaluation in artificially-infected paraffin-embedded tissues. PCR was then applied to post-mortem, paraffin-embedded sample
Rev. Inst. Med. trop. S. Paulo. Publicado em: 2014-09
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12. Editorial
Malaria is still a primary health problem in Colombia. The locality of Tierradentro is situated in the municipality of Montelíbano, Córdoba, in the northwest of Colombia, and has one of the highest annual parasite index of malaria nationwide. However, the vectors involved in malaria transmission in this locality have not yet been identified. In this study,
Mem. Inst. Oswaldo Cruz. Publicado em: 20/05/2014