Selective Estrogen Receptor Modulators
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. Pharmacological management of osteogenesis
Osteogenesis and bone remodeling are complex biological processes that are essential for the formation of new bone tissue and its correct functioning. When the balance between bone resorption and formation is disrupted, bone diseases and disorders such as Paget's disease, fibrous dysplasia, osteoporosis and fragility fractures may result. Recent advances in
Clinics. Publicado em: 2014-06
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2. Atividade anticâncer in vitro e in vivo de Psidium guajava L. (nome popular: goiabeira) / Psidium guajava L. (popular name guava) in vitro and in vivo anticancer activity
Anticancer drug research based on screening of natural sources enabled the discovery of several drugs that are used in cancer treatment. This project aimed to evaluate the in vitro and in vivo anticancer activity of Psidium guajava L. (popular name: guava), elected for its ethnopharmacological use for antiparasitic activity. After harvesting, the vegetal mat
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/02/2011
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3. AVALIAÇÃO DO EFEITO ESTROGÊNICO DO GINKGO BILOBA EM RATAS WISTAR IMPÚBERES
The use of hormonal therapy in menopause is not absent of risks being related to adverse effects such as pulmonary embolism and cancer due to its use. In these cases, phytoestrogens, the estrogenic compounds present in plants, can be used as an alternative to the hormonal treatment. There is already proof of efficacy and safety in their use. Ginkgo biloba ex
Publicado em: 2009
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4. Advances in breast cancer treatment and prevention: preclinical studies on aromatase inhibitors and new selective estrogen receptor modulators (SERMs)
Intensive basic and clinical research over the past 20 years has yielded crucial molecular understanding into how estrogen and the estrogen receptor act to regulate breast cancer and has led to the development of more effective, less toxic, and safer hormonal therapy agents for breast cancer management and prevention. Selective potent aromatase inhibitors ar
BioMed Central.
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5. Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta - regulation by selective estrogen receptor modulators and importance in breast cancer
Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone replacement, and for fertility regulation. Certain compounds that act through the estrogen receptor (ER), now referred to as selective estrogen recepto
BioMed Central.
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6. Molecular determinants of tissue selectivity in estrogen receptor modulators
Interaction of the estrogen receptor/ligand complex with a DNA estrogen response element is known to regulate gene transcription. In turn, specific conformations of the receptor-ligand complex have been postulated to influence unique subsets of estrogen-responsive genes resulting in differential modulation and, ultimately, tissue-selective outcomes. The estr
The National Academy of Sciences of the USA.
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7. Selective Estrogen Receptor Modulators 4-Hydroxytamoxifen and Raloxifene Impact the Stability and Function of SRC-1 and SRC-3 Coactivator Proteins
Proteasome-mediated protein degradation has been implicated in playing a role in nuclear receptor-mediated gene expression; inhibition of the proteasome impairs the transcriptional activity of estrogen receptor α (ERα) and most other nuclear receptors. This coincides with blockage of agonist-dependent degradation of the receptor and elevation of the steady
American Society for Microbiology.
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8. Estradiol and Selective Estrogen Receptor Modulators Differentially Regulate Target Genes with Estrogen Receptors α and βD⃞
Estrogens and selective estrogen receptor modulators (SERMs) interact with estrogen receptor (ER) α and β to activate or repress gene transcription. To understand how estrogens and SERMs exert tissue-specific effects, we performed microarray analysis to determine whether ERα or ERβ regulate different target genes in response to estrogens and SERMs. We pr
The American Society for Cell Biology.
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9. Differential effects on bone of estrogen receptor α and androgen receptor activation in orchidectomized adult male mice
Androgens may regulate the male skeleton either directly by stimulation of the androgen receptor (AR) or indirectly by aromatization of androgens into estrogens and, thereafter, by stimulation of the estrogen receptors (ERs). To directly compare the effect of ER activation on bone in vivo with the effect of AR activation, 9-month-old orchidectomized wild-typ
National Academy of Sciences.
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10. Estradiol and Tamoxifen Mediate Rescue of the Dominant-Negative Effects of Estrogen Response Element-Binding Protein in Vivo and in Vitro
Biological responses to estrogens are dependent on the integrated actions of proteins, including the estrogen receptor (ER)-α, that regulate the transcription of estrogen response element (ERE)-containing target genes. We have identified a naturally occurring ERE antagonist, termed an ERE-binding protein (BP). To verify that ERE-BP can induce estradiol (E2)
The Endocrine Society.
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11. Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor α
Steroid hormone receptors (SHRs) are ligand-activated transcription factors that regulate gene expression. SHRs also mediate rapid, nongenomic cellular activation by steroids. In vascular endothelial cells, the SHR for estrogen, estrogen receptor (ER) α, is targeted by unknown mechanisms to a functional signaling module in membrane caveolae that enables est
National Academy of Sciences.
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12. Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand
Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) is a transcriptional coactivator that is a key component in the regulation of energy production and utilization in metabolic tissues. Recent work has identified PGC-1α as a strong coactivator of the orphan nuclear receptor estrogen-related receptor α (ERRα), implicating ERRα
National Academy of Sciences.