Secretory Phospholipase A2
Mostrando 1-12 de 69 artigos, teses e dissertações.
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1. Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort
Resumo Objetivo: A atividade da enzima fosfolipase A2 secretória (sPLA2) é um possível biomarcador inflamatório de doença cardiovascular. Examinamos o monitoramento, ou a persistência, dos níveis de atividade da enzima sPLA2 da infância à vida adulta e identificamos fatores possivelmente modificáveis que afetam o monitoramento. Método: Coorte pr
J. Pediatr. (Rio J.). Publicado em: 11/04/2019
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2. Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculata
Abstract Background Mass spectrometry-guided venom peptide profiling is a powerful tool to explore novel substances from venomous animals in a highly sensitive manner. In this study, this peptide profiling approach is successfully applied to explore the venom peptides of a Japanese solitary carpenter bee, Xylocopa appendiculata (Hymenoptera: Apoidea: Apida
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/07/2017
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3. Sulfated polysaccharide extracted of the green algae Caulerpa racemosa increase the enzymatic activity and paw edema induced by sPLA2 from Crotalus durissus terrificus venom
Sulfated polysaccharides derived from seaweed have shown great potential for use in the development of new drugs. In this study, we observed that a low-molecular-weight sulfated polysaccharide from Caulerpa racemosa, termed CrSP, could interact with secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus terrificus venom. When native sPLA2 (14 kDa
Rev. bras. farmacogn.. Publicado em: 02/08/2013
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4. Avaliação da glicosilação não enzimática (glicação) sobre a fosfolipases A2 secretórias pró-inflamatórias isoladas de venenos de serpentes / Evaluation of non enzymatic glycosylation (glycation) on phospholipase A2 secretory pro-inflammatory isolated from snake venoms
O objetivo deste trabalho foi avaliar o efeito de glicações sobre a PLA2 secretórias isoladas do veneno das serpentes Crotalus durissus collilineatus e Bothrops jararacussu. A técnica de MALDI-TOF foi usado para comprovar a glicação dos carboidratos nas PLA2: a PLA2 de Cdcolli apresentou glicação a 6 moléculas de D-Glicose e de 5 moléculas de D-Lac
Publicado em: 2011
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5. Avaliação dos efeitos da quercetina e hecogenina sobre a atividade farmacológica e enzimática induzida por sPLA2 isoladas de venenos crotálicos e botrópicos / Evaluation of effects of quercetin and hecogenin on the pharmacological and enzymatic activities iduced by sPLA2
Nas últimas décadas, o uso de compostos naturais como flavonóides e sapogeninas tem sido largamente difundidos na indústria farmacêutica devido suas atividades antiinflamatórias, prevenção de câncer e de doenças cardiovasculares. Neste trabalho, foi avaliado o efeito da quercetina (flavonóide) e hecogenina (sapogenina), sobre as atividades catalí
Publicado em: 2011
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6. Atividade enzimática dos subtipos de fosfolipase A2 (PLA2) em cultura primária de neurônios / Activity of phospholipase A2 (PLA2) subtypes in primary cultures of rat cortical neurons
The phospholipase (PLA2) is considered a key enzyme in the metabolism of phospholipids, which are the main constitutes of cellular membranes. Alterations in PLA2 activity have been reported in the brain and blood cells of psychiatric patients and also in biological matrixes like rat brain tissues and cultures of neuron cells. Inhibition of PLA2 activity in p
Publicado em: 2009
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7. Efeitos do veneno de Crotalus durissus terrificus, da crotoxina e de suas subunidades fosfolipase A2 e crotapotina em monocamadas de células endoteliais em cultura. / Effects of the venom of Crotalus durissus terrificus from crotoxina and its subunits and crotapotina phospholipase A2 in monolayers of endothelial cells in culture.
Crotalus durissus terrificus snake venom (CdtV) and their components induces systemic effects, which interfere with blood vessel system. Endothelial cells (EC) are central elements for haemostasis, regulating blood vessel-wall permeability, blood fluidity and adhesion properties of circulating leukocytes. However, there is no available data on the effects of
Publicado em: 2009
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8. Modulação do mecanismo de sedreção de insulina em ilhotas pancreaticas de ratos submetidos a restrição protetica e suplementados com taurina / Insulin secretion mechanisms in pancreatic islets of protein-restricted rats supplemented with taurine
Malnutrition still is a public health issue, especially in developing countries. Many studies correlate malnourishment during early life and the development of cardiovascular disease and type 2 Diabetes Mellitus on latter stages. Animal models of malnutrition reveal impaired insulin secretion stimulated by glucose and other insulinotropic agents as well as l
Publicado em: 2009
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9. Diversidade molecular e funcional de proteínas da saliva de triatoma infestans,um vetor da doença de chagas
Triatoma infestans is one of the most important vectors of Chagas Disease in Latin America, feeding on vertebrate blood in all life stages. Hematophagous insects salivary glands produce potent pharmacological compounds that counteract host hemostasis, including anti-clotting, anti-platelet, and vasodilatory molecules. The saliva of T. infestans mediates hydr
Publicado em: 2007
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10. Effects ot genetic hypercholesterolemia on the glycemic homeostasis and insulin secretion in LDL recptor knockout mice ( LDLR POT. -/- ) / Efeito da hipercolesterolemia genetica sobre a homeostase glicemica e secreção de insulina em camundongos knockout para o recptor de LDL ( LDLR POT. -/- )
In this work, we investigated whether primary hyperlipidemia per se, independently of a high-fat diet, affects glycemia and insulin secretion stimulated by several secretagogues in hypercholesterolemic low-density lipoprotein receptor knockout mice (LDLR-/-). In addition, we investigated the possible mechanisms involved in the release of this hormone. We fou
Publicado em: 2007
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11. Development of methods to access phospholipase A2 fraction activity in platelets / "Desenvolvimento de métodos para determinação da atividade das frações da fosfolipase A2 em plaquetas"
Phospholipase A2 (PLA2) is a key-enzyme in the metabolism of membrane phospholipids and is one of the major components involved in cell signaling. Alterations of PLA2 activity have been reported in brains and blood cells in several neuropsychiatric diseases. In this study we developed a radio-enzymatic assay to detect in platelets the activity of the three m
Publicado em: 2006
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12. Secretory Phospholipase A2 Is the Principal Bactericide for Staphylococci and Other Gram-Positive Bacteria in Human Tears
We examined human tears for molecules that killed gram-positive bacteria. The principal mediator of bactericidal activity against staphylococci proved to be a calcium-dependent enzyme, secretory phospholipase A2. Whereas the concentration of secretory phospholipase A2 in the normal tear film exceeded 30 μg/ml, only 1.1 ng (<0.1 nM) of the enzyme per ml suff
American Society for Microbiology.