Secretory Lysosome Granules
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Dualidade funcional das células uNK de camundongos durante a gestação / Dual capacities of mice uNK cells
Células Natural Killer uterina (uNK) produzem moléculas angiogênicas e citocinas críticas ao sucesso da gestação , assim como proteínas citolíticas relacionadas à resposta imune inata. Contudo, se as capacidades angiogênicas e citolíticas são provenientes de diferentes subpopulações de células uNK não é conhecido; da mesma forma, estes fenó
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/02/2012
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2. Efeito da lesão embrionaria nos granulos lisossomo-secretores das celulas natural killer uterinas de camundongos / Effect of embryo lesion on secretory-lysosome granules of mice uterine-natural killer cells
Durante a gestação normal em primatas e em roedores observa-se o acúmulo de linfócitos natural killer no ambiente uterino (uNK). A funções comprovadas das células uNK estão relaciondas com o reconhecimento das células trofoblásticas alogênicas e produção de citocinas imunomoduladoras do ambiente uterino que garantem o sucesso da gestação. Alé
Publicado em: 2006
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3. Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation
The monomeric small GTPase Rab27a is specifically localized on both secretory granules and lysosome-related organelles. Although natural mutations of the Rab27a gene in human Griscelli syndrome and in ashen mice cause partial albinism and immunodeficiency reflecting the dysfunction of lysosome-related organelles, phenotypes resulting from the defective exocy
American Society for Clinical Investigation.
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4. Regional differences in the ultrastructural features of secretory cells in the golden hamster (Mesocricetus auratus) oviductal epithelium.
The secretory cells of the golden hamster (Mesocricetus auratus) oviductal epithelium on the day of ovulation were observed by light and electron microscopy. In the fimbriae two types of secretory cells were observed: one possessed secretory granules with electron-lucent matrices, prominent protrusions and many electron-dense granules resembling lipid drople
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5. Munc13-4 Is an Effector of Rab27a and Controls Secretion of Lysosomes in Hematopoietic Cells
Griscelli syndrome type 2 (GS2) is a genetic disorder in which patients exhibit life-threatening defects of cytotoxic T lymphocytes (CTLs) whose lytic granules fail to dock on the plasma membrane and therefore do not release their contents. The disease is caused by the absence of functional rab27a, but how rab27a controls secretion of lytic granule contents
The American Society for Cell Biology.
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6. Lack of Fusion of Azurophil Granules with Phagosomes during Phagocytosis of Mycobacterium smegmatis by Human Neutrophils Is Not Actively Controlled by the Bacterium
Biogenesis of phagolysosomes is a very rapid event in neutrophils which takes place with nascent unclosed phagosomes, leading to the release of lysosomal enzymes such as β-glucuronidase in the extracellular medium. We have previously shown that, under nonopsonic conditions, both pathogenic and nonpathogenic mycobacteria uncouple phagocytosis from fusion of
American Society for Microbiology.
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7. Acidification of macrophage and fibroblast endocytic vesicles in vitro.
We have used the pH-dependent fluorochrome fluorescein-dextran (FD) to study the acidification of prelysosomal vacuoles (endosomes) and lysosomes isolated from cultured macrophages and fibroblasts. FD was internalized by pinocytosis under conditions that allowed its selective localization in endosomes (1- to 5-min pulse) or in lysosomes (5-min pulse, 30-min