Salmonella Microsome
Mostrando 13-24 de 33 artigos, teses e dissertações.
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13. Genotoxic, neurotoxic and neuroprotective activities of apomorphine and its oxidized derivative 8-oxo-apomorphine
Apomorphine is a dopamine receptor agonist proposed to be a neuroprotective agent in the treatment of patients with Parkinson's disease. Both in vivo and in vitro studies have shown that apomorphine displays both antioxidant and pro-oxidant actions, and might have either neuroprotective or neurotoxic effects on the central nervous system. Some of the neuroto
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-04
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14. Cashew (Anacardium occidentale) apple juice lowers mutagenicity of aflatoxin B1 in S. typhimurium TA102
Cashew (Anacardium occidentale) is a medicinal plant native to Brazil and also yields a nutritious fruit juice. Its large pulpy pseudo-fruit, referred to as the cashew apple, contains high concentrations of vitamin C, carotenoids, phenolic compounds and minerals. Natural and processed cashew apple juice (CAJ/cajuina) are amongst the most popular juices in Br
Genetics and Molecular Biology. Publicado em: 2005
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15. Mutagenicity of the mycotoxin emodin in the salmonella/microsome system.
The mycotoxin emodin was found to be a frameshift mutagen for Salmonella typhimurium strain TA 1537 after metabolic activation in a mammalian microsome system.
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16. Mutagenicity of 5,6-dimethoxysterigmatocystin, a metabolite from Aspergillus multicolor, in the Salmonella/microsome system.
The natural sterigmatocystin derivative, 5,6-dimethoxysterigmatocystin, was found to be a mutagen for Salmonella typhimurium strains TA98 and TA100 after metabolic activation in a mammalian microsome system.
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17. Mutagenicity of anthraquinone and hydroxylated anthraquinones in the Ames/Salmonella microsome system.
The mutagenicity of anthracene, anthraquinone, and four structurally similar compounds of each was evaluated in the Ames/Salmonella microsome assay. Anthraquinone was shown to be mutagenic for strains TA1537, TA1538, and TA98 in the absence of rat liver homogenate. The four anthraquinone derivatives tested were mutagenic for TA1537 exclusively. None of the a
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18. Statistical analysis of the Ames Salmonella/microsome test.
A family of statistical models for analysis of Ames Salmonella/microsome test data is constructed that considers mutation and toxicity as competing risks and allows hyper-Poisson variability. These models have a parameter than can be employed as a mutagenic index because it approximates the slope at zero dose of a dose-response curve adjusted for toxicity. A
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19. Mutagenicity of islandicin and chrysophanol in the Salmonella/microsome system.
Chrysophanol and islandicin, two anthraquinones which are structurally related to emodin, were found to be frame-shift mutagens for Salmonella typhimurium strain TA 1537 after metabolic activation.
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20. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.
About 300 carcinogens and non-carcinogens of a wide variety of chemical types have been tested for mutagenicity in the simple Salmonella/microsome test. The test uses bacteria as sensitive indicators for DNA damage, and mammalian liver extracts for metabolic conversion of carcinogens to their active mutagenic forms. Quantitative mutagenicity data from linear
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21. Lack of Mutagenicity of the Fungicide 2,4,5,6-Tetrachloroisophthalonitrile in the Ames Salmonella/Microsome Test
The fungicide 2,4,5,6-tetrachloroisophthalonitrile was found to be not mutagenic to five Salmonella typhimurium tester strains. Incorporation of either a liver or a kidney activation system did not increase the mutagenic activity of the fungicide.
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22. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.
About 300 carcinogens and non-carcinogens of a wide variety of chemical types have been tested for mutagenicity in the simple Salmonella/microsome test. The test uses bacteria as sensitive indicators of DNA damage, and mammalian liver extracts for metabolic conversion of carcinogens to their active mutagenic forms. There is a high correlation between carcino
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23. Mollicellins: mutagenic and antibacterial mycotoxins.
Eight mollicellins (depsidones) were assayed for mutagenicity and antibacterial activity in Salmonella/microsome tests involving histidine reversion and forward mutation to 8-azaguanine resistance. Two of them, mollicellins C and E, which contain a 3-methylbutenoic acid moiety, were mutagenic and bactericidal for Salmonella typhimurium in the absence of micr
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24. Production of a mutagen from ponceau 3R by a human intestinal anaerobe.
Ponceau 3R was reduced in vitro by Fusobacterium sp. 2, a human intestinal anaerobe, to a product which is mutagenic when metabolically activated by liver S9 preparations in the Salmonella/mammalian-microsome mutagenicity test. This mutagenic metabolite has been identified as 2,4,5-trimethylaniline.