S Mansoni Antigens
Mostrando 1-12 de 74 artigos, teses e dissertações.
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1. Evaluation of the immunogenicity of Schistosoma mansoni egg surface
Abstract INTRODUCTION Immunogenicity of Schistosoma mansoni egg surface was examined to determine whether intact eggshells have lower antigenicity than ruptured eggs. METHODS: Swiss Webster mice were inoculated with intact or ultrasonicated S. mansoni eggs isolated from infected human feces. Mice were separated into four groups of six animals each and im
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-09
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2. Association between allergic responses and Schistosoma mansoni infection in residents in a low-endemic setting in Brazil
Introduction Schistosomiasis is endemic in 76 countries and territories. Several studies have found an inverse correlation between parasitic disease and the development of allergies. The purpose of the present study was to determine whether infect
Rev. Soc. Bras. Med. Trop.. Publicado em: 2014-12
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3. Schistosoma mansoni antigens alter the cytokine response in vitro during cutaneous leishmaniasis
Schistosoma mansoni infection or associated products are able to down-modulate the type 1 CD4+ T cell inflammatory response characteristic of autoimmune diseases. In this study, we evaluated how S. mansoni antigens altered the immune response that was induced by the soluble Leishmania antigen (SLA) from cutaneous leishmaniasis (CL) patients. Cytokines were m
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-11
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4. Identification of Schistosoma mansoni candidate antigens for diagnosis of schistosomiasis
The development of a more sensitive diagnostic test for schistosomiasis is needed to overcome the limitations of the use of stool examination in low endemic areas. Using parasite antigens in enzyme linked immunosorbent assay is a promising strategy, however a more rational selection of parasite antigens is necessary. In this study we performed in silico anal
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-11
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5. Antibody reactivity against potato apyrase, a protein that shares epitopes with Schistosoma mansoni ATP diphosphohydrolase isoforms, in acute and chronically infected mice, after chemotherapy and reinfection
Schistosoma mansoni ATP diphosphohydrolase isoforms and potato apyrase share conserved epitopes. By enzyme-linked immunosorbent assays, elevated levels of IgM, IgG2a and IgG1 antibody reactivity against potato apyrase were observed in S. mansoni-infected BALB/c mice during the acute phase of infection, while only IgM and IgG1 antibody reactivity levels maint
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-07
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6. Modulação da resposta imune alérgica por antígenos de Schistosoma mansoni
A prevalência das doenças alérgicas vem aumentando nas últimas três décadas, representando um grande problema de saúde pública. A infecção pelo Schistosoma mansoni tem sido associada com a proteção contra alergias. Os mecanismos envolvidos nesta associação incluem a produção de células e citocinas regulatórias. Objetivo: Avaliar a resposta
Publicado em: 2009
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7. Study of the vaccine potencial of proteins from Schistosoma mansoni using atenuated recombinant salmonellas as vehicle for antigen presentation to the host / Estudo do potencial vacinal de proteínas de Schistosoma mansoni utilizando salmonelas atenuadas recombinantes como veículo para apresentação de antígenos ao hospedeiro
Schistosomiasis is one of the most important endemic diseases in the world, with more than 200 million people infected in 76 countries. It is estimated that more than 600 million people live in endemic areas. In 2003 extensive data from the transcriptome of Schsitosoma mansoni was made available. The information on the encoded proteins allowed the analysis o
Publicado em: 2009
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8. Avaliação da imunogenicidade de epitopos de células T das proteínas Sm14 e paramiosina do schistosoma mansoni em modelo murino.
Sm14 and paramyosin are S. mansoni antigens able to induce partial protection in the murine model, and are recognized by individuals resistant to S. mansoni. Recently our group has identified Sm14 and paramyosin epitopes preferentially recognized by PBMC of S. mansoni resistant individuals [Sm14 (32-48), Sm14 (53-69), Para (6-22), Para (210-226), Para (355-3
Publicado em: 2008
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9. Biochemical and immunological characterization of ATP- diphosphohydrolases 1 and 2 from Schistosoma mansoni parasite / Caracterização bioquímica e imunológica das enzimas recombinantes ATP-difosfohidrolases 1 e 2 do parasita Schistosoma mansoni
ATPDases or ATP-diphosphohydrolases are enzymes that cleave ATP and ADP to AMP and Pi and are involved in inhibition of platelet aggregation. In the parasite Schistosoma mansoni our group had identified and cloned the ATPDase1 gene and localized the protein on the tegument surface. Recently, we cloned the ATPDase2 gene using S. mansoni EST databank informati
Publicado em: 2008
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10. Treatment of human acute schistosomiasis with oxamniquine induces an increase in interferon-gamma response to Schistosoma mansoni antigens
Patients with acute schistosomiasis were studied before and after oxamniquine treatment. They had been exposed to cercariae 5 to 9 weeks before, and presented compatible clinical manifestations, eosinophilia, and high levels of total IgE. Interferon-gamma (IFN-gamma) and interleukin-4 were measured by ELISA in whole blood samples under soluble egg antigen or
Memórias do Instituto Oswaldo Cruz. Publicado em: 16/02/2007
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11. Células de doadores normais primadas in vitro respondem ao antígeno ovular solúvel e ao peptídeo sintético MAP4 derivado da triose fosfato isomerase do Schistosoma mansoni. / Cells of normal primed givers in vitro answer to the antigen to ovular soluble and synthetic peptíde MAP4 derived from triose-phosphate isomerase of the Schistosoma mansoni.
It has been well established that Schistosoma mansoni induces an initial CD4+ T-cell response. The early events in the immune response to schistosomiasis have been evaluated in mice but few studies have focused on the early response in humans, especially in regard to parasite antigens that are potential vaccine candidates. To study the early immune response
Publicado em: 2007
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12. Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
Asthmatics infected with Schistosoma mansoni have a less severe course of asthma and an inhibition of the Th2 inflammatory response that seems to be mediated by interleukin (IL-10). The objective of this study was to evaluate the capacity of some S. mansoni antigens to stimulate IL-10 production in vitro by cells of asthmatic infected individuals. Peripheral
Memórias do Instituto Oswaldo Cruz. Publicado em: 2006-10