Rodent Malaria
Mostrando 1-12 de 86 artigos, teses e dissertações.
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1. The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine
The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/k
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-09
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2. Estudos de fisiologia comparativa de modelos de malária em roedor. / Comparative physiology studies of rodent malaria models.
Malária é um dos principais problemas de saúde nos países em desenvolvimento sendo o Plasmodium o agente etiológico da doença. Neste trabalho foi investigada a função do Ca2+ e da sinalização purinérgica na modulação proteolítica de Plasmodium. Utilizando peptídeos com apagamento intracelular de fluorescência (FRET) analisamos a atividade pro
Publicado em: 2010
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3. Células progenitoras CD34+ durante a ampliação esplênica na malária experimental de roedores. / CD34+ progenitor cells during spleen amplification in experimental rodent malaria.
A malária é uma infecção causada por plasmódios, cujo controle depende do baço, o responsável pelo clareamento dos eritrócitos parasitos. O aumento da parasitemia induz uma ampliação do baço para resolver a infecção, onde participam células precursoras que apresentam CCD34+ na sua superfície. Estudamos a distribuição e a quantidade de célul
Publicado em: 2007
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4. Interruption of the blood-stage cycle of the malaria parasite, Plasmodium chabaudi, by protein tyrosine kinase inhibitors
Malaria is a devastating disease caused by a unicellular protozoan, Plasmodium, which affects 3.7 million people every year. Resistance of the parasite to classical treatments such as chloroquine requires the development of new drugs. To gain insight into the mechanisms that control Plasmodium cell cycle, we have examined the effects of kinase inhibitors on
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-11
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5. Attenuated vaccinia virus-circumsporozoite protein recombinants confer protection against rodent malaria.
NYVAC-based vaccinia virus recombinants expressing the circumsporozoite protein (CSP) were evaluated in the Plasmodium berghei rodent malaria model system. Immunization of mice with a NYVAC-based CSP recombinant elicited a high level of protection (60 to 100%). Protection did not correlate with CS repeat-specific antibody responses and was abrogated by in vi
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6. Knockout of the Rodent Malaria Parasite Chitinase PbCHT1 Reduces Infectivity to Mosquitoes
During mosquito transmission, malaria ookinetes must cross a chitin-containing structure known as the peritrophic matrix (PM), which surrounds the infected blood meal in the mosquito midgut. In turn, ookinetes produce multiple chitinase activities presumably aimed at disrupting this physical barrier to allow ookinete invasion of the midgut epithelium. Plasmo
American Society for Microbiology.
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7. Plasmodium interspersed repeats: the major multigene superfamily of malaria parasites
Functionally related homologues of known genes can be difficult to identify in divergent species. In this paper, we show how multi-character analysis can be used to elucidate the relationships among divergent members of gene superfamilies. We used probabilistic modelling in conjunction with protein structural predictions and gene-structure analyses on a whol
Oxford University Press.
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8. Antimalarial Activities of Novel Synthetic Cysteine Protease Inhibitors
Among promising new targets for antimalarial chemotherapy are the cysteine protease hemoglobinases falcipain-2 and falcipain-3. We evaluated the activities of synthetic peptidyl aldehyde and α-ketoamide cysteine protease inhibitors against these proteases, against cultured Plasmodium falciparum parasites, and in a murine malaria model. Optimized compounds i
American Society for Microbiology.
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9. Hypoglycemia and hyperinsulinemia in rodent models of severe malaria infection.
Severe hypoglycemia developed during nonlethal Plasmodium chabaudi and lethal P. yoelii blood stage malaria infection in mice, always in association with hyperinsulinemia. Supernatants of lethal P. yoelii incubated overnight induced hypoglycemia and hyperinsulinemia in normal mice. In murine malaria, hypoglycemia may be largely secondary to increased insulin
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10. Complement-mediated Defect in Clearance and Sequestration of Sensitized, Autologous Erythrocytes in Rodent Malaria
We investigated the ability of malaria-infected and normal mice to clear particulate immune complexes consisting of autologous erythrocytes sensitized with either IgG or complement.
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11. Sulfadoxine-Pyrimethamine Resistance in the Rodent Malaria Parasite Plasmodium chabaudi
American Society for Microbiology.
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12. Murine malaria parasite sequestration: CD36 is the major receptor, but cerebral pathology is unlinked to sequestration
Sequestration of malaria-parasite-infected erythrocytes in the microvasculature of organs is thought to be a significant cause of pathology. Cerebral malaria (CM) is a major complication of Plasmodium falciparum infections, and PfEMP1-mediated sequestration of infected red blood cells has been considered to be the major feature leading to CM-related patholog
National Academy of Sciences.