Rna Splicing
Mostrando 1-12 de 2817 artigos, teses e dissertações.
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1. Identification and Characterisation of Alternative Splice Variants of Hoxb9 and Their Correlation with Melanogenesis in the Black-Boned Chicken
ABSTRACT Homeobox B9 (HOXB9) gene has been demonstrated to be associated with melanogenesis in chicken plumage by high-throughput RNA sequencing. In this study, we cloned and characterised HOXB9 in black-boned chickens. Two alternative splice variants (HOXB9-1 and HOXB9-2) were identified in chicken feather bulbs. Expression analysis of HOXB9 in 11 differen
Braz. J. Poult. Sci.. Publicado em: 19/08/2019
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2. Minimum free energy predicted base pairing in the 39 nt spliced leader and 5’ UTR of calmodulin mRNA from Trypanosoma cruzi: influence of the multiple trans-splicing sites
ABSTRACT We analyzed the compositional changes and the stable base pairs in the predicted secondary structure of the 5’ UTR calmodulin mRNA in T. cruzi. The three copies of calmodulin in T. cruzi genome display variable position of the trans splicing sites and give rise to several mRNA that differs slightly on 5’ UTR composition in the epimastigote stage
An. Acad. Bras. Ciênc.. Publicado em: 16/10/2017
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3. Optimized Exon-Exon Junction Library and its Application on Rodents' Brain Transcriptome Analysis
ABSTRACT Background: Alternative splicing (AS), which plays an important role in gene expression and functional regulation, has been analyzed on genome-scale by various bioinformatic approaches based on RNA-seq data. Compared with the huge number of studies on mouse, the AS researches approaching the rat, whose genome is intermedia between mouse and human,
Braz. arch. biol. technol.. Publicado em: 02/05/2017
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4. Benchmarking pathway interaction network for colorectal cancer to identify dysregulated pathways
Different pathways act synergistically to participate in many biological processes. Thus, the purpose of our study was to extract dysregulated pathways to investigate the pathogenesis of colorectal cancer (CRC) based on the functional dependency among pathways. Protein-protein interaction (PPI) information and pathway data were retrieved from STRING and Reac
Braz J Med Biol Res. Publicado em: 30/03/2017
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5. RNA-binding proteins and their role in the regulation of gene expression in Trypanosoma cruzi and Saccharomyces cerevisiae
Abstract RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein compl
Genet. Mol. Biol.. Publicado em: 2017-03
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6. Splicing factor SF3B1 mutations and ring sideroblasts in myelodysplastic syndromes: a Brazilian cohort screening study
ABSTRACT Background: Myelodysplastic syndromes (MDS) comprise a group of malignant clonal hematologic disorders characterized by ineffective hematopoiesis and propensity for progression to acute myeloid leukemia. Acquired mutations in the gene encoding RNA splicing factor 3B subunit 1 (SF3B1) are highly associated with the MDS subtypes presenting ring sider
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-12
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7. A directed approach for the identification of transcripts harbouring the spliced leader sequence and the effect of trans-splicing knockdown in Schistosoma mansoni
Schistosomiasis is a major neglected tropical disease caused by trematodes from the genus Schistosoma. Because schistosomes exhibit a complex life cycle and numerous mechanisms for regulating gene expression, it is believed that spliced leader (SL) trans-splicing could play an important role in the biology of these parasites. The purpose of this study was to
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-09
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8. Identification of alternative transcripts of rat CD9 expressed by tumorigenic neural cell lines and in normal tissues
CD9 is the best-studied member of the tetraspanin family of transmembrane proteins. It is involved in various fundamental cellular processes and its altered expression is a characteristic of malignant cells of different origins. Despite numerous investigations confirming its fundamental role, the heterogeneity of CD9 or other tetraspanin proteins was conside
Genet. Mol. Biol.. Publicado em: 2013
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9. Investigating he signature of natural selection on exonic splicing regulators of the human genome / Análise dos sinais de seleção natural em reguladores de splicing exônicos do genoma humano
Splicing is the process by which introns are removed from a mRNA precursor and exons are ligated to form a mature mRNA. During this process several cis and trans factors are involved. Besides the canonical cis factors (e.g., splicing sites, branch point and polypyrimidine tract), Splicing Regulators - short sequences located in exons and introns - have an im
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/06/2012
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10. Biogênese, estabilidade e localização sub-celular de RNAs não-codificadores longos expressos em regiões intrônicas do genoma humano / Biogenesis, stability and sub-cellular localization of long non-coding RNAs expressed in intronic regions of the human genome
Trabalhos recentes indicam que a maior parte do transcriptoma de células de mamíferos é composto por RNAs não-codificadores de proteínas (ncRNAs). Nosso grupo tem identificado e caracterizado ncRNAs longos (>200 nt), sem splicing, expressos em regiões intrônicas de genes codificadores de proteína. Contudo, a biogênese, processamento e localização
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/03/2012
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11. Identification of SL addition trans-splicing acceptor sites in the internal transcribed spacer I region of pre-rRNA in Leishmania (Leishmania) amazonensis
Trypanosomatidae is a family of early branching eukaryotes harbouring a distinctive repertoire of gene expression strategies. Functional mature messenger RNA is generated via the trans-splicing and polyadenylation processing of constitutively transcribed polycistronic units. Recently, trans-splicing of pre-small subunit ribosomal RNA in the 5' external trans
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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12. Footprints of a trypanosomatid RNA world: pre-small subunit rRNA processing by spliced leader addition trans-splicing
The addition of a capped mini-exon [spliced leader (SL)] through trans-splicing is essential for the maturation of RNA polymerase (pol) II-transcribed polycistronic pre-mRNAs in all members of the Trypanosomatidae family. This process is an inter-molecular splicing reaction that follows the same basic rules of cis-splicing reactions. In this study, we demons
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-06