Rifampin And Isoniazid Bioavailability
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Estudo da barreira funcional intestinal e concentraÃÃes sÃricas de rifampicina e isoniazida em pacientes com tuberculose multirresistente / Intestinal barrier function and bioavailability of rifampin and isoniazid in multidrug-resistant tuberculosis patients in cearà state, northeast-brazil
Baixos nÃveis sangÃÃneos de drogas antituberculose podem ser causa de resistÃncia do Mycobacterium tuberculosis. Este estudo objetivou avaliar a absorÃÃo intestinal transcelular e paracelular e verificar possÃvel repercussÃo nas concentra-ÃÃes sÃricas de de rifampicina (RMP) e isoniazida (INH) em pacientes com tuberculose multirresistente (TBMR).
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/06/2009
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2. Barreira funcional intestinal, absorÃÃo e biodisponibilidade de Rifampicina, Isoniazida e Pirazinamida em pacientes com tuberculose pulmonar ativa / Functional intestinal barrier, absorption and bioavailability of Rifampin, Isoniazid and Pyrazinamide in patients with active pulmunary tuberculosis
Baixas concentraÃÃes sÃricas de drogas antituberculose podem ser causa da resistÃncia de Mycobacterium tuberculosis Ãs drogas utilizadas para tratamento, a qual à mais freqÃente em pacientes em tratamento irregular, mas pode ser verificada em pacientes em tratamento diretamente observado. Os objetivos desse estudo foram avaliar a permeabilidade intest
Publicado em: 2007
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3. Intestinal permeability and malabsorption of rifampin and isoniazid in active pulmonary tuberculosis
Low antimycobacterial drug concentrations have been observed in tuberculosis (TB) patients under treatment. The lactulose/mannitol urinary excretion test (L/M), normally used to measure intestinal permeability, may be useful to assess drug absorption. The objective of this research was to study intestinal absorptive function and bioavailability of rifampin a
Brazilian Journal of Infectious Diseases. Publicado em: 2006-12
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4. Decreased Bioavailability of Rifampin and Other Antituberculosis Drugs in Patients with Advanced Human Immunodeficiency Virus Disease
We evaluated the effects of human immunodeficiency virus (HIV) disease on pharmacokinetics of antituberculosis medications by measuring concentrations of isoniazid and rifampin in blood and of pyrazinamide and ethambutol in urine. Peak concentration and exposure were reduced for rifampin, and rapid acetylators of isoniazid had lower drug levels. HIV and HIV-
American Society for Microbiology.
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5. Chemotherapeutic Potential of Orally Administered Poly(Lactide-Co-Glycolide) Microparticles Containing Isoniazid, Rifampin, and Pyrazinamide against Experimental Tuberculosis
Poly(lactide-co-glycolide) (PLG) microspheres (diameter, less than 3 μm) containing isoniazid, rifampin, and pyrazinamide were used in a sustained oral drug delivery system to treat murine tuberculosis. Drug levels above the MIC were observed up to 72 h in plasma and for 9 days in various organs. Relative bioavailability of encapsulated drugs was greater th
American Society for Microbiology.
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6. Epithelial cells in culture as a model for the intestinal transport of antimicrobial agents.
The bioavailabilities of orally administered drugs depend to a great extent on their capability of being transported across the intestinal mucosa. In an attempt to develop an in vitro model for studying the intestinal transport of drugs, we used an intestinal epithelial cell line (Caco 2) derived from a human colon adenocarcinoma. A renal epithelial cell lin