Redox Protective Activity
Mostrando 1-12 de 14 artigos, teses e dissertações.
-
1. Hepatoprotective effect of Alhagi sparsifolia against Alcoholic Liver injury in mice
Overconsumption of alcohol leads to alcoholic liver disease (ALD). Natural compounds have been investigated previously for their hepatoprotective activities against liver injury. This study investigated the protective effect of Alhagi sparsifolia on ALD. Alcohol was administered to mice for three consecutive days; either alone or in combination with Alhagi s
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
-
2. Therapeutic concentration of morphine reduces oxidative stress in glioma cell line
Morphine is a potent analgesic opioid used extensively for pain treatment. During the last decade, global consumption grew more than 4-fold. However, molecular mechanisms elicited by morphine are not totally understood. Thus, a growing literature indicates that there are additional actions to the analgesic effect. Previous studies about morphine and oxidativ
Braz J Med Biol Res. Publicado em: 11/04/2014
-
3. ATIVIDADE REDOX-PROTETORA DA PASSIFLORA CINCINNATA MAST SOBRE O ESTRESSE OXIDATIVO INDUZIDO PELO EXERCÍCIO FÍSICO. / PROTECTIVE ACTIVITY OF REDOX-PASSIFLORA CINCINNATA MAST ON OXIDATIVE STRESS INDUCED BY EXERCISE.
Nos últimos anos, têm aumentado o interesse em avaliar o efeito de constituintes fitoquímicos presentes em alimentos e chás de ervas na atenuação do estresse oxidativo associado ao exercício físico de alta intensidade. Nesse contexto, o chá das folhas de plantas do gênero Passiflora pode inibir o dano celular causado pelo estresse oxidativo devido
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/03/2011
-
4. Avaliação das propriedades antigenotóxicas e antioxidantes do flavonóide quercetina e dos carotenóides bixina e norbixina contra os danos no material genético e distúrbios do estado redox causados pelo cloreto de mercúrio e metilmercúrio, in vitro e in vivo / Evaluation of antigenotoxic and antioxidant properties of the flavonoid quercetin and of the carotenoid bixin and norbixin against DNA-damage and alterations of redox status induced by mercury chloride and methylmercury, in vitro and in vivo
Mercury (Hg) is one of the most hazardous metals in the environment and the major process responsible for its toxicity is oxidative damage; its organic form methylmercury (MeHg) presents the highest toxicity. The main way of exposition to Hg is through inhalation by workers occupationally exposed in several industries and/or through consumption of fishes and
Publicado em: 2011
-
5. Estudo fitoquímico biomonitorado da entrecasca de maytenus rigida mart. (celastraceae)
The chosen plant belongs to the family Celastracea which comprehends about 85 genders and from 800 to 900 species with wide distribution in the tropical and subtropical regions of the world. In this family the gender Maytenus highlights due to a great variety of bioactive metabolites. From this gender, the specie Maytenus rigida Mart was collected in the vil
Publicado em: 2006
-
6. Protective effects of the glutathione redox cycle and vitamin E on cultured fibroblasts infected by Mycoplasma pneumoniae.
The role of the glutathione (GSH) redox cycle and vitamin E as antioxidant defense systems was studied in normal human cultured skin fibroblasts infected by virulent Mycoplasma pneumoniae. In cells infected for 20 h, catalase activity was inhibited by 75% and the intracellular GSH decreased to 32% of its normal values. GSH peroxidase and oxidized glutathione
-
7. A mechanism of paraquat toxicity involving nitric oxide synthase
Paraquat (PQ) is a well described pneumotoxicant that produces toxicity by redox cycling with cellular diaphorases, thereby elevating intracellular levels of superoxide (O2⨪). NO synthase (NOS) has been shown to participate in PQ-induced lung injury. Current theory holds that NO reacts with O2⨪ generated by PQ to produce the toxin peroxynitrite. We asked
The National Academy of Sciences.
-
8. Phosphorylation is not essential for protection of L929 cells by Hsp25 against H2O2 -mediated disruption actin cytoskeleton, a protection which appears related to the redox change mediated by Hsp25
Small stress proteins protect against the cytotoxicity mediated by oxidative stress. The relationship between Hsp25 expression and the integrity of the actin network was studied in H2O2-treated murine L929 fibrosarcoma cells overexpressing endogenous wild-type (wt-) or non-phosphorylatable mutant (mt-) Hsp25. We show here that both proteins prevented actin n
Cell Stress Society International.
-
9. Oxidative Stress-Induced Calcium Signaling in Arabidopsis1
Many environmental stresses result in increased generation of active oxygen species in plant cells. This leads to the induction of protective mechanisms, including changes in gene expression, which lead to antioxidant activity, the recovery of redox balance, and recovery from damage/toxicity. Relatively little is known about the signaling events that link pe
American Society of Plant Biologists.
-
10. Oncogenic conversion of Ets affects redox regulation in-vivo and in-vitro.
The avian acute leukemia virus E26 encodes a fusion protein between viral Gag and the cellular transcription factors cMyb and cEts1(p68). vEts on its own transforms more mature erythroid cells. We have compared the properties of vEts and cEts1(p68). vEts interacts preferentially with an antibody that recognizes the active conformation of the DNA-binding doma
-
11. Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.
Thioredoxin is a small ubiquitous protein with multiple biological functions, including cellular defense mechanisms against oxidative stress. In the present study, we investigated the role of human thioredoxin (hTRX) in the acquisition of cellular resistance to cis-diamminedichloroplatinum (II) (CDDP). The expression and activity of hTRX in Jurkat T cells wa
-
12. Dimerization of thiol-specific antioxidant and the essential role of cysteine 47.
Thiol-specific antioxidant (TSA) from yeast contains cysteine residues at amino acid positions 47 and 170 but is not associated with obvious redox cofactors. These two cysteines are highly conserved in a family of proteins that exhibit sequence identity of 23-98% with TSA. The roles of Cys-47 and Cys-170 in yeast TSA were investigated by replacing them indiv