Recombinogenic
Mostrando 1-12 de 118 artigos, teses e dissertações.
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1. Recombinogenic activity of Pantoprazole® in somatic cells of Drosophila melanogaster
Pantoprazole® is one of the leading proton pump inhibitors (PPIs) used in the treatment of a variety of diseases related to the upper gastrointestinal tract. However, studies have shown an increased risk of developing gastric cancer, intestinal metaplasia and hyperplasia of endocrine cells with prolonged use. In the present study, the somatic mutation and r
Genet. Mol. Biol.. Publicado em: 2015-03
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2. Avaliação do potencial mutagênico, recombinogênico e carcinogênico do Orlistat em células somáticas de Drosophila melanogaster
CHAPTER 2: Orlistat is the first compound of a new pharmacological class which limits dietary fat absorption by inhibiting gastric and pancreatic lipases. It does not affect the neuronal circuits regulating appetite, and its action consists basically of obstructing digestion of dietary triglycerides. Recent researches suggest that orlistat stops the growth o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/07/2011
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3. Genotoxic effect of alkaloids
Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showe
Publicado em: 2010
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4. Genotoxic evaluation of sodium nitroprusside in Aspergillus nidulans
The exogenous nitric oxide donor, sodium nitroprusside, evaluated the recombinogenic potential of nitric oxide. Drug inhibited mycelial growth and conidiation in A757 Aspergillus nidulans master strain. Two heterozygous diploid strains, one wild (uvsH+//uvsH+) and the other defective to DNA repair (uvsH//uvsH) were used for recombinagenesis tests. Sodium nit
Genetics and Molecular Biology. Publicado em: 2005-12
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5. A simple method for the detection of recombinogenic substances in filamentous fungi
Muitos são os testes conhecidos para detectar produtos mutagênicos e recombinogênicos em fungos. Pelo fato de os fungos serem eucarióticos, estes testes permitem detectar não só substâncias que produzem aberrações cromossômicas, mas também substâncias recombinogênicas. Este trabalho apresenta um novo método para testar substâncias que afetam a
Genetics and Molecular Biology. Publicado em: 2000-06
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6. BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54
Mutation of BLM helicase results in the autosomal recessive disorder Bloom syndrome (BS). Patients with BS exhibit hyper-recombination and are prone to almost all forms of cancer. BLM can exhibit its anti-recombinogenic function either by dissolution of double Holliday junctions or by disruption of RAD51 nucleofilaments. We have now found that BLM can in
Company of Biologists.
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7. A PIF-dependent recombinogenic signal in the mitochondrial DNA of yeast
From their recombination properties, tandem rho- mutants of the mitochondrial genome of Saccharomyces cerevisiae were divided into two categories. In crosses between PIF-independent rho- and rho+ strains, the recombination frequency is low and similar in PIF/pif and pif/pif diploids. In crosses between PIF-dependent rho- and rho+ strains, the recombination f
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8. A DNA-recombinogenic activity in human cells.
A DNA recombining protein has been partly purified from cell lines derived from patients suffering from the hereditary disease, Bloom's syndrome. The protein induces the formation of displacement loops in phi X174 RFI DNA molecules after the addition of single-stranded DNA fragments. A filter binding method and electron microscopy were used to determine the
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9. DNA from recombinogenic lambda bacteriophages generated by arl mutant of Escherichia coli is cleaved by single-strand-specific endonuclease S1.
When propagated on arl strains (a subclass of Escherichia coli hyper-rec mutants), lambda "Red-" duplication phages accumulated an enhanced potential for recombination. The physical properties of the recombinogenic phages thus obtained ("Arl-" phages) were similar to those of phages grown on arl+ bacteria. However, Arl- phage DNA was cleaved by endonuclease
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10. Fuzzy species among recombinogenic bacteria
BioMed Central.
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11. The Recombinogenic Effect of Thymidylate Starvation in ESCHERICHIA COLI Merodiploids
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12. Lambda Red-mediated recombinogenic engineering of enterohemorrhagic and enteropathogenic E. coli
BioMed Central.