Recombinant Human Bone Morphogenetic Protein
Mostrando 1-12 de 19 artigos, teses e dissertações.
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1. Collagen sponge and rhBMP-2 improve socket healing in rats treated with zoledronic acid
Abstract The aim of the present study was to evaluate the possible use of a commercial absorbed collagen sponge and bone morphogenetic protein (BMP) for the prevention of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in rats. Twenty rats received intraperitoneal injections of 0.1-mg/kg of zoledronic acid three times a week for eight weeks before th
Braz. oral res.. Publicado em: 07/12/2017
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2. In vivo performance of different scaffolds for dental pulp stem cells induced for odontogenic differentiation
Abstract This study was designed to determine the in vivo performance of three different materials as scaffolds for dental pulp stem cells (DPSC) undergoing induced odontogenic differentiation. An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. Mesenc
Braz. oral res.. Publicado em: 28/11/2016
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3. Minimally traumatic alveolar ridge augmentation with a tunnel injectable thermo-sensitive alginate scaffold
Injectable bone substitutes and techniques have been developed for use in minimally invasive procedures for bone augmentation. Objective : To develop a novel injectable thermo-sensitive alginate hydrogel (TSAH) as a scaffold to induce bone regeneration, using a minimally invasive tunnelling technique. Material and Methods : An injectable TSAH was prepared fr
J. Appl. Oral Sci.. Publicado em: 2015-04
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4. Addition of bone morphogenetic protein type 2 to ascorbate and β-glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells. OBJECTIVES: This study evaluated the effect of a recombinant BMP-2 as well as the endogenous BMP-4 and BMP-7 in the osteogenic differentiation of adipose-derived stem cells (ASCs) in mediu
J. Appl. Oral Sci.. Publicado em: 2012-12
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5. Pulpal and periapical response of dogs teeth after pulpotomy and use of bone morphogenetic protein (rHuBMP-7). Histopathologic and radiographic study. / Resposta pulpar e periapical de dentes de cães após pulpotomia e utilização da proteína óssea morfogenética (rHuBMP-7). Estudo histopatológico e radiográfico
O objetivo deste estudo foi a avaliação histopatológica e radiográfica da resposta pulpar e periapical de dentes de cães após pulpotomia e utilização da Proteína Morfogenética Óssea Recombinante Humana 7. Foram utilizados 60 dentes (120 raízes) de 6 cães, divididos em 8 grupos, nos períodos experimentais de 7 dias (Grupos I, II, III, IV) e 70 d
Publicado em: 2006
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6. Estudo imunoistoquimico da incorporação de enxerto alogeno com proteina morfogenetica do osso-2 na mandibula de rato
Large bone defects can be managed by autogenous graft; however limitations in this source have induced research for new materials to replace autogenous graft. The incorporation of autoclaved alogenous bone graft associated to recombinant human bone morphogenetic protein 2 (rhBMP-2) was the objective of this study. The study animals were 75 Wistar rats distri
Publicado em: 2004
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7. Recombinant human bone morphogenetic protein induces bone formation.
We have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 micrograms of partially purified rec
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8. Drosophila transforming growth factor beta superfamily proteins induce endochondral bone formation in mammals.
Both decapentaplegic (dpp) protein and 60A protein have been implicated in pattern formation during Drosophila melanogaster embryogenesis. Within the C-terminal domain, dpp and 60A are similar to human bone morphogenetic protein 2 (75% identity) and human osteogenic protein 1 (70% identity), respectively. Both recombinant human bone morphogenetic protein 2 a
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9. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression.
Subcutaneous implantation of demineralized bone matrix initiates a sequence of developmental events, which culminate in endochondral bone formation. During early stages of development of matrix-induced implants, ED1, Ia-positive monocytes-macrophages were observed, suggesting that in the initial phases of the endochondral bone formation cascade, the bone-ind
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10. Identification and characterization of cellular binding proteins (receptors) for recombinant human bone morphogenetic protein 2B, an initiator of bone differentiation cascade.
Bone morphogenetic protein 2B (BMP 2B), is a heparin-binding bone differentiation factor that initiates endochondral bone formation in rats when implanted subcutaneously. The molecular mechanism of action of this differentiation factor is not known, and as a first step we have examined BMP 2B-responsive cells for the presence of specific cellular binding pro
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11. Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15
Oocyte-derived growth factors are critically involved in multiple ovarian processes via paracrine actions. Although recombinant proteins have been applied to dissect the physiological functions of these factors, variation of activities among different protein preparations remains an issue. To further elucidate the roles of one of these growth factors, bone m
Oxford University Press.
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12. Porous bone morphogenetic protein-2 microspheres: Polymer binding and in vitro release
This research compared the binding and release of recombinant human bone morphogenetic protein 2 (rhBMP-2) with a series of hydrophobic and hydrophilic poly-lactide-co-glycolide (PLGA) copolymers. Porous microspheres were produced via a double emulsion process. Binding and incorporation of protein were achieved by soaking microspheres in buffered protein sol
Springer-Verlag.