Recombinant Antigens
Mostrando 13-24 de 1187 artigos, teses e dissertações.
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13. Comparison of recombinant A2-ELISA with rKE16 dipstick and direct agglutination tests for diagnosis of visceral leishmaniasis in dogs in Northwestern Iran
INTRODUCTION: Various methods are used for the diagnosis of visceral leishmaniasis (VL), such as microscopic examination, culture and inoculation of laboratory animals; however, serological assays are commonly used for the detection of antibodies in serum samples with a wide range of specificity and sensitivity. METHODS: The purpose of this study was to com
Rev. Soc. Bras. Med. Trop.. Publicado em: 2015-04
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14. The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response
We studied the feasibility of using halloysite clay nanotubes (HNTs) and carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen carriers to improve immune responses against a recombinant LipL32 protein (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the rLipL32-specific IgG antibody titres (p < 0.05) of G
Mem. Inst. Oswaldo Cruz. Publicado em: 23/01/2015
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15. Live bacterial vaccine vectors: An overview
Genetically attenuated microorganisms, pathogens, and some commensal bacteria can be engineered to deliver recombinant heterologous antigens to stimulate the host immune system, while still offering good levels of safety. A key feature of these live vectors is their capacity to stimulate mucosal as well as humoral and/or cellular systemic immunity. This enab
Braz. J. Microbiol.. Publicado em: 2014-12
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16. A Saint Louis encephalitis and Rocio virus serosurvey in Brazilian horses
Introduction Arboviruses are an important public health problem in Brazil, in especially flaviviruses, including the Saint Louis encephalitis virus (SLEV) and the Rocio virus (ROCV), are especially problematic. These viruses are transmitted to humans or other vertebrates through arthropod bites and may cause diseases with clinical manifestations that range
Rev. Soc. Bras. Med. Trop.. Publicado em: 2014-08
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17. Development and validation of a genotype 3 recombinant protein-based immunoassay for hepatitis E virus serology in swine
Hepatitis E virus (HEV) is classified within the family Hepeviridae, genus Hepevirus. HEV genotype 3 (Gt3) infections are endemic in pigs in Western Europe and in North and South America and cause zoonotic infections in humans. Several serological assays to detect HEV antibodies in pigs have been developed, at first mainly based on HEV genotype 1 (Gt1) antig
Braz J Med Biol Res. Publicado em: 21/03/2014
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18. Evaluation of CD4+CD25+ T lymphocyte response time kinetics in patients with chronic Chagas disease after in vitro stimulation with recombinant Trypanosoma cruzi antigens
Introduction CD4+CD25+ T lymphocytes have been implicated in the regulation of host inflammatory response against Trypanosoma cruzi, and may be involved in the clinical course of the disease. Methods Peripheral blood mononuclear cells from patients with chronic Chagas disease were cultured in the presence of T. cruzi recombinant antigens and assayed for l
Rev. Soc. Bras. Med. Trop.. Publicado em: 10/05/2013
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19. Desempenho de antígenos nativo, recombinante e sintético, em testes imunoenzimáticos, para diagnóstico e prognóstico de pacientes com diferentes formas clínicas de hanseníase / Performance of native, recombinant and synthetic antigens by enzyme immunoassays for the diagnosis and prognosis of leprosy patients classified in the wide spectrum of the disease
Apesar da Organização Mundial de Saúde (OMS) ter adotado medidas de controle, a hanseníase permanece como um problema social e de saúde pública em muitos países. O diagnóstico clínico e a baciloscopia permanecem como as principais ferramentas utilizadas para a classificação dos pacientes e definição da terapêutica a ser instituída. A identific
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/11/2012
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20. Production and characterization of recombinant chimeras C and D of Clostridium botulinum / Produção e caracterização de quimeras recombinantes C e D de Clostridium botulinum
Bovine Botulism is a lethal intoxication caused by the ingestion of the neurotoxins produced by Clostridium botulinum types C and D that inhibit the release of acetylcholine at the neuromuscular junction leading to death by flaccid paralysis. It produces important economic losses, being a major cause of casualties in cattle in several regions of Brazil. The
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/08/2012
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21. Análise da resposta imune induzida pela imunização experimental com antígenos recombinantes de Plasmodium vivax / Analysis of the immune response induced by experimental immunization with recombinant antigens of Plasmodium vivax
A malária é uma das prioridades da pesquisa mundial na área de desenvolvimento de vacinas. Apesar da contínua e crescente atividade de pesquisa nessa área, ainda não existe uma vacina capaz de impedir a infecção pelo Plasmodium spp. Devido ao complexo ciclo de vida deste agente, uma formulação vacinal eficaz para a indução de uma resposta imune p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2012
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22. Identification of serological biomarkers of infection, disease progression and treatment efficacy for leprosy
Although leprosy is curable with drug treatment, the identification of biomarkers of infection, disease progression and treatment efficacy would greatly help to reduce the overall prevalence of the disease. Reliable biomarkers would also reduce the incidence of grade-2 disability by ensuring that those who are most at risk are diagnosed and treated early or
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
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23. Recombinant vaccines and the development of new vaccine strategies
Vaccines were initially developed on an empirical basis, relying mostly on attenuation or inactivation of pathogens. Advances in immunology, molecular biology, biochemistry, genomics, and proteomics have added new perspectives to the vaccinology field. The use of recombinant proteins allows the targeting of immune responses focused against few protective ant
Braz J Med Biol Res. Publicado em: 2012-12
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24. Serologic follow-up of IgG responses against recombinant mycobacterial proteins ML0405, ML2331 and LID-1 in a leprosy hyperendemic area in Venezuela
Leprosy is a slowly evolving disease that occurs mainly in adults. In this study, the Mamaría Village, state of Portuguesa was selected because it had one of the highest prevalence rates (13.25%) of leprosy cases in 1997. Between 1998-2004, 20.2% of the 89 cases registered in this village were less than 15 years old and 61.8% were males. Pau-cibacillary (PB
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12