Receptors Ldl
Mostrando 13-24 de 199 artigos, teses e dissertações.
-
13. Proteomic analisys of bovine yolk sac / Análise proteômica do saco vitelino de bovinos
The yolk sac plays an important role in embryonic development of all mammals. Its function is being studied, proving to be one of the initials of haematopoiesis. In the period when the placenta is not real yet formed during embryonic development, the yolk sac is the main source of nutrition of the embryo, providing a place for the transfer and synthesis of p
Publicado em: 2009
-
14. A 7-ketocholesterol containing-nanoemulsion (LDE/7KC) inhibits growth of melanoma tumor in mice and increases survival rate / Nanoemulsão contendo 7-cetocolesterol (LDE/7KC) promove inibição do crescimento de melanoma em camundongos e aumento de sobrevida
7-ketocholesterol (7KC) is an oxysterol known to inhibit cell proliferation and to be cytotoxic. A nanoemulsion containing-7KC (LDE/7KC) was shown to have antiproliferative effects on RPMI 8226 myeloma cell line and melanoma (B16F10), in vitro. This particle is taken up mainly by LDL receptors. Here we have evaluated the plasma kinetic, biodistribution, anti
Publicado em: 2007
-
15. Uso de uma nanoemulsão rica em colesterol (LDE) como veículo para o di-dodecil metotrexato / Use of a cholesterol-rich nanoemulsion (LDE) as vehicle for di-dodecyl methotrexate
O uso da LDE como veículo para quimioterápicos tem mostrado ser uma boa estratégia para aumentar a eficácia terapêutica dos mesmos. Nesse estudo, a LDE foi empregada como veículo para um derivado lipofílico do metotrexato (MTX), o di-dodecil metotrexato, que foi obtido com rendimento elevado através de reação de esterificação do MTX. O aumento na
Publicado em: 2007
-
16. Effects ot genetic hypercholesterolemia on the glycemic homeostasis and insulin secretion in LDL recptor knockout mice ( LDLR POT. -/- ) / Efeito da hipercolesterolemia genetica sobre a homeostase glicemica e secreção de insulina em camundongos knockout para o recptor de LDL ( LDLR POT. -/- )
In this work, we investigated whether primary hyperlipidemia per se, independently of a high-fat diet, affects glycemia and insulin secretion stimulated by several secretagogues in hypercholesterolemic low-density lipoprotein receptor knockout mice (LDLR-/-). In addition, we investigated the possible mechanisms involved in the release of this hormone. We fou
Publicado em: 2007
-
17. Plasma kinetics and biodistribution of free cholesterol and cholesterol ester of a nanoemulsion that binds to LDL receptors in animals without and with atherosclerosis / Cinética plasmática e biodistribuição de colesterol livre e colesterol esterificado de uma nanoemulsão (LDE) que se liga aos receptores de LDL em animais controle e com indução de aterosclerose
I n previously studies, it was shown that free cholesterol (FC) and cholesterol ester (CE) of a cholesterol-rich nanoemulsion (LDE) behaves differently in patients with coronary artery disease (CAD). The FC plasma clearance and arterial deposition is greater than CE. In the present study we evaluate the plasma kinetics, estimated by the fractional clearance
Publicado em: 2007
-
18. Reversão do fenótipo de resistência a múltiplas drogas em células de sarcoma uterino humano. Utilização de emulsão lipídica como veículo de oligonucleotídeos antissenso / Reversion of the multiple drug resistance phenotype in a human sarcoma cell line. Lipid emulsion as antisense oligonucleotide vector
The objective of this study was to evaluate the usefulness of a nanolipid emulsion (LDE) as a vector to carry antisense oligonucleotides (OAS). LDE is a nanoemulsion consisting of 48% cholesterol esters, 47,8% phospholipid, 2,3% triglycerides and 1,9% unesterified cholesterol. It is able to obtain apoE from HDL and interact with B/E receptor. The metabolic b
Publicado em: 2007
-
19. Uso de emulsão lipídica como veículo do paclitaxel na terapia sistêmica do carcinoma da mama / Use of a lipidic emulsion as vehicle of paclitaxel in systemic therapy of breast cancer
INTRODUÇÃO: Estudos mostraram que, após a injeção de LDE na corrente sangüínea de mulheres portadoras de câncer de mama, ela encontra-se mais concentrada em tecido neoplásico que no tecido normal. Recentemente, estudos pré-clínicos comprovaram que a associação LDE-oleato de paclitaxel é estável, menos tóxica e com mais atividade terapêutica
Publicado em: 2006
-
20. Expressão de citocinas, quimiocinas e seus receptores em celulas mononucleares do sangue periferico de pacientes com doença arterial coronariana / Expression of cytokines, chemokines receptors in peripheral blood mononuclear cells from patients with coronary arthery disease
Pesquisas recentes têm demonstrado que a aterosclerose é uma doença inflamatória crônica. Diversos componentes que participam da resposta imunológica inata e adaptativa foram descritos nas lesões e estão relacionados com o início e progressão das mesmas. Monócitos/macrófagos, linfócitos e células endoteliais possuem papel central na patogênese
Publicado em: 2006
-
21. Estrogen replacement therapy and cardioprotection: mechanisms and controversies
Epidemiological and case-controlled studies suggest that estrogen replacement therapy might be beneficial in terms of primary prevention of coronary heart disease (CHD). This beneficial effect of estrogens was initially considered to be due to the reduction of low density lipoproteins (LDL) and to increases in high density lipoproteins (HDL). Recent studies
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-03
-
22. In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells
Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors. LDE is a lipid microemulsion easily synthesized in vitro which is known to mimic the metabolic pathway of LDL. We used LDE as a carrier for daunorubicin and assayed the cytotoxicity of the
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-10
-
23. Uptake of cholesterol-rich remnant lipoproteins by human monocyte-derived macrophages is mediated by low density lipoprotein receptors.
The uptake and degradation of cholesterol-rich remnant lipoproteins, referred to as beta-VLDL, are shown in the present study to be mediated by LDL receptors (apoB,E(LDL) receptors), not by unique beta-VLDL receptors. Human blood monocytes cultured for 5-7 d bound apoB- and/or apoE-containing lipoproteins from different species with affinities equivalent to
-
24. In vivo evidence for reduced binding of low density lipoproteins to receptors as a cause of primary moderate hypercholesterolemia.
The causes of primary moderate hypercholesterolemia are not understood, but some patients have reduced fractional clearance rates (FCRs) for low density lipoproteins (LDL). This could be due to either decreased activity of LDL receptors or to a defect in structure (or composition) of LDL that reduces its affinity for receptors. To distinguish between these c