Real Activity
Mostrando 1-12 de 666 artigos, teses e dissertações.
-
1. Antitumor activity of irinotecan with ellagic acid in C6 glioma cells
SUMMARY OBJECTIVE: Irinotecan-based combination chemotherapies in malignant gliomas need to be examined. The aim of this study was to investigate the synergetic effect of ellagic acid, a natural polyphenolic antioxidant compound, with irinotecan, an inhibitor of topoisomerase I enzyme, on the growth, cadherin switch, and angiogenic processes of a glioma cel
Revista da Associação Médica Brasileira. Publicado em: 2022
-
2. Newborns at high risk for brain injury: the role of the amplitude-integrated electroencephalography
Abstract Objective: Amplitude-integrated electroencephalography (aEEG) is a simplified bedside neurophysiology tool that has been implemented in the neonatal intensive care unit and studied in an extensive range of clinical applications in the past decade. This critical review aimed to evaluate a variety of clinical applications of aEEG monitoring in diagno
Jornal de Pediatria. Publicado em: 2022
-
3. Oxidative Stress and Changes of Important Metabolic Gene Expressions as a Potential Biomarker in the Diagnosis of Atherosclerosis in Leukocytes
ABSTRACT Introduction: Presenilin 1 (PSEN1), catalase (CAT), glutathione-S-transferase (GST) and paraoxonase 1 (PON1) play a vital role in prediction, diagnosis and therapy of metabolic disorders. Methods: Metabolic enzyme activities and lipid peroxidation in serum of cerebrovascular diseases (CVD) and coronary artery diseases were measured by spectrophoto
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
-
4. MicroRNA-124a Protects the Myocardium Against Ischemia Reperfusion Injury Through Regulation of the Notch Signaling Pathway
Abstract Introduction: This study’s objective is to investigate the effect of downregulation of micro ribonucleic acid (miR)-124a on myocardial injury after ischemia reperfusion (I/R) in rats. Methods: Sprague Dawley (SD) rats (n=20) were divided into four groups - sham, I/R, I/R+miR-124a antagomir (I/R+ant-miR-124a), and I/R+ant-normal control (NC). The
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
-
5. T3 therapy for hypothyroidism: choosing wisely still requires careful bench to bedside translation
ABSTRACT Objective: To study the association of SLC16A11 gene variants with obesity and metabolic markers in nondiabetic Chilean adults. Materials and methods: This cross-sectional study included 263 non-diabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. It's association with adiposity markers (bod
Arch. Endocrinol. Metab.. Publicado em: 2021-06
-
6. Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population
ABSTRACT Objective: To study the association of SLC16A11 gene variants with obesity and metabolic markers in nondiabetic Chilean adults. Materials and methods: This cross-sectional study included 263 non-diabetic adults. The genotype of the rs75493593 polymorphism of SLC16A11 gene was performed by real-time PCR. It's association with adiposity markers (bod
Arch. Endocrinol. Metab.. Publicado em: 2021-06
-
7. Blood microRNA expressions in patients with mild to moderate psoriasis and the relationship between microRNAs and psoriasis activity,
Abstract Background: In recent studies, microRNAs (mi-RNAs) have been shown to play an important role in psoriasis pathogenesis. However, studies evaluating mi-RNAs in the blood of psoriasis patients including a large number of mi-RNA panels are scarce. Objective: The authors aimed to assess mi-RNA expressions in blood samples of psoriasis patients, as wel
An. Bras. Dermatol.. Publicado em: 2020-12
-
8. Chronic low back pain and physical activity among patients within the Brazilian National Health System: a cross-sectional study
BACKGROUND: This study was based on filling a gap in our knowledge regarding the issue of what the protective effect of physical exercise on patients within the Brazilian National Health System could be, in relation to low back pain. OBJECTIVES: To determine the prevalence of chronic low back pain (CLBP) and to analyze the protective effect of physical ex
Sao Paulo Med. J.. Publicado em: 2020-03
-
9. OTIMIZAÇÃO E VALIDAÇÃO DE MÉTODO BASEADO EM QuEChERS PARA DETERMINAÇÃO DE CONSERVANTES EM COSMÉTICOS POR HPLC-DAD
Parabens are widely used as preservatives in the last decades. Others preservatives such as 2-phenoxyethanol, which in addition to his good antimicrobial activity, has low allergenic potential as well others properties of interest to the cosmetic industry. In this work was developed a method for determination of methylparaben (MP), propylparaben (PP) and 2-p
Quím. Nova. Publicado em: 2020-02
-
10. Antifungal and Photocatalytic Activity of Smart Paint Containing Porous Microspheres of TiO2
In this study, porous microspheres of TiO2 (µTiO2) were synthesized, characterized and incorporated into an acrylic paint formulation to obtain a photocatalytically active paint. In a novel approach, the antifungal properties of the µTiO2 paint were evaluated using Monascus ruber as the representative microorganism and compared to those of a photocatalyst-
Mat. Res.. Publicado em: 20/01/2020
-
11. THEORETICAL-METHODOLOGICAL CONTRIBUTIONS OF ERGOLOGY TO RESEARCH ON WORK IN THE NURSING AREA
RESUMO Objetivo: o presente estudo consiste em uma reflexão teórica, com objetivo de sistematizar aspectos conceituais e metodológicos da perspectiva ergológica, destacando contribuições para pesquisas sobre o trabalho da enfermagem. Método: construído com base em textos escolhidos de autores que assumem a perspectiva ergológica para estudar o t
Texto contexto - enferm.. Publicado em: 09/12/2019
-
12. The role of NMDA receptor antagonists, amantadine and memantine, in schizophrenia treatment: a systematic review
Abstract Objective Schizophrenia is a complex and chronic psychiatric disorder. In recent years, studies have found glutamatergic system participation in its etiopathogenesis, especially through aberrant NMDA receptors functioning. Thus, drugs that modulate this activity, as amantadine and memantine, could theoretically be used in its treatment. To perform
Arch. Clin. Psychiatry (São Paulo). Publicado em: 28/11/2019